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Cardiovascular Research 2006 70(2):264-273; doi:10.1016/j.cardiores.2006.02.024
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Copyright © 2006, European Society of Cardiology

Mitochondrial permeability transition pore and postconditioning

Odile Gateau-Roesch, Laurent Argaud and Michel Ovize*

INSERM E 0226, Université Claude Bernard Lyon I, 8 Avenue Rockefeller, 69373 Lyon cedex 08, France
Hôpital Louis Pradel, Hospices Civils de Lyon, 69437 Lyon cedex 03, France

* Corresponding author. Inserm E0226-Laboratoire de Physiologie Lyon-Nord, 8, avenue Rockefeller, 69373 Lyon, France. Tel.: +33 4 78 77 70 74; fax: +33 4 78 77 71 75. Email address: ovize{at}sante.univ-lyon1.fr

Postconditioning has recently been described as a powerful cardioprotection that prevents lethal reperfusion injury. Growing evidence suggests that mitochondrial permeability transition may be a key event in postconditioning. This proposition arises from the complementary observations that: (1) conditions for the mitochondrial permeability transition pore (mPTP) opening are built up during early reperfusion, (2) mPTP opens at the time of reperfusion, (3) transgenic structural alteration of mPTP modifies its opening probability following ischemia–reperfusion, (4) mPTP plays a role in preconditioning, and (5) postconditioning attenuates lethal reperfusion injury. We review in this article current evidence for an important role of the mitochondrial transition pore in postconditioning.

KEYWORDS Ischemia; Reperfusion; Mitochondria

Time for primary review 26 days


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