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Cardiovascular Research 2006 70(1):42-49; doi:10.1016/j.cardiores.2005.11.029
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Copyright © 2006, European Society of Cardiology

Caveolae and caveolin in transmembrane signaling: Implications for human disease

Carsten Schwencke1, Ruediger C. Braun-Dullaeus, Carsten Wunderlich and Ruth H. Strasser*

University of Technology, Dresden, Medical Clinic/Cardiology, Fetscherstr. 76, D-01307 Dresden, Germany

* Corresponding author. Tel.: +49 351 450 1701 (office); fax: +49 351 450 1702. Email address: ruth.strasser{at}mailbox.tu-dresden.de

The identification of various signaling molecules found within caveolae and their functional interaction with the integral membrane protein caveolin, a major structural component of caveolae, suggests that these membrane microdomains participate in transmembrane signaling. Several lines of evidence indicate that caveolin may act as a scaffolding protein by direct interaction with and modulation of the activity of multiple signaling molecules. The compartmentation of various signaling molecules in caveolae and their direct and functional interaction with caveolin provides a paradigm by which these membrane microdomains are involved in regulating signal transduction pathways. By dysregulation of these signal transduction pathways caveolins may be involved in the pathogenesis of various diseases. This review focuses on the implications as well as controversies of the contribution of caveolae and caveolins for several human diseases and the potential implications to therapeutic strategies.

KEYWORDS Caveolae; Caveolin; Human disease; Atherosclerosis; Restenosis; Malignancies

1 Current address: Universitäres Herz-und Gefäβzentrum Hamburg, Prof. Mathey, Prof. Schofer and Partner, Othmarscher Kirchenweg 168, 22763 Hamburg, Germany.

Time for primary review 22 days


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