Copyright © 2006, European Society of Cardiology
Caveolins and the regulation of endothelial nitric oxide synthase in the heart
Unit of Pharmacology and Therapeutics, FATH 5349, Department of Medicine, Université catholique de Louvain, 53 avenue Mounier, 1200 Brussels, Belgium
* Corresponding author. Tel.: +32 2 764 9326; fax: +32 2 764 9322. Email address: Balligand{at}mint.ucl.ac.be
Virtually all cell types within the myocardium express caveolae, where cell-specific isoforms of caveolin both maintain the structural organisation of these cholesterol-rich of the plasmalemma and serve as scaffolds for the dynamic constitution of "signalosomes", or hubs concentrating numerous transmembrane signaling proteins and their effectors. Analysis of the phenotype of mice with genetic deletion or overexpression of specific caveolin isoforms has provided key evidence for the importance of caveolins and caveolae in several aspects of the cardiovascular biology, including vascular contractility, lipid metabolism, angiogenesis, or the control of cardiac hypertrophy. Among specific protein–protein interactions involving caveolins in cardiac tissue, these genetic models unequivocally confirmed the functional importance of the dynamic association of the endothelial isoform of nitric oxide synthase (eNOS) for its post-translational regulation in endothelial cells and cardiac myocytes, which bears on the enzyme's capacity to modulate nitric oxide (NO)-dependent endothelial function, angiogenesis, and excitation–contraction coupling. We will review the current understanding of this regulation of eNOS (and potentially other NOS isoforms) through protein–protein interactions involving several G-protein-coupled receptors and other allosteric modulators in the context of emerging paradigms on the regulation of cardiac function by NO.
KEYWORDS Nitric oxide synthase; Caveolin; Endothelium; Cardiac myocytes; Angiogenesis; Contractility
Time for primary review 24 days
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
S.-H. Chang, D. Feng, J. A. Nagy, T. E. Sciuto, A. M. Dvorak, and H. F. Dvorak Vascular Permeability and Pathological Angiogenesis in Caveolin-1-Null Mice Am. J. Pathol., October 1, 2009; 175(4): 1768 - 1776. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. N. Dedkova and L. A. Blatter Characteristics and function of cardiac mitochondrial nitric oxide synthase J. Physiol., February 15, 2009; 587(4): 851 - 872. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Krenek, J. Kmecova, D. Kucerova, Z. Bajuszova, P. Musil, A. Gazova, P. Ochodnicky, J. Klimas, and J. Kyselovic Isoproterenol-induced heart failure in the rat is associated with nitric oxide-dependent functional alterations of cardiac function Eur J Heart Fail, February 1, 2009; 11(2): 140 - 146. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Le Saux, K. Teeters, S. Miyasato, J. Choi, G. Nakamatsu, J. A. Richardson, B. Starcher, E. C. Davis, E. K. Tam, and C. Jourdan-Le Saux The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties Am J Physiol Lung Cell Mol Physiol, December 1, 2008; 295(6): L1007 - L1017. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. M. Tsutsumi, Y. T. Horikawa, M. M. Jennings, M. W. Kidd, I. R. Niesman, U. Yokoyama, B. P. Head, Y. Hagiwara, Y. Ishikawa, A. Miyanohara, et al. Cardiac-Specific Overexpression of Caveolin-3 Induces Endogenous Cardiac Protection by Mimicking Ischemic Preconditioning Circulation, November 4, 2008; 118(19): 1979 - 1988. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. L. Quinlan, A. D. T. Costa, C. L. Costa, S. V. Pierre, P. Dos Santos, and K. D. Garlid Conditioning the heart induces formation of signalosomes that interact with mitochondria to open mitoKATP channels Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H953 - H961. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Ruiz-Hurtado, M. Fernandez-Velasco, M. Mourelle, and C. Delgado LA419, a Novel Nitric Oxide Donor, Prevents Pathological Cardiac Remodeling in Pressure-Overloaded Rats Via Endothelial Nitric Oxide Synthase Pathway Regulation Hypertension, December 1, 2007; 50(6): 1049 - 1056. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. H. Patel, S. Zhang, F. Murray, R. Y. S. Suda, B. P. Head, U. Yokoyama, J. S. Swaney, I. R. Niesman, R. T. Schermuly, S. S. Pullamsetti, et al. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension FASEB J, September 1, 2007; 21(11): 2970 - 2979. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. M. Dudzinski and T. Michel Life history of eNOS: Partners and pathways Cardiovasc Res, July 15, 2007; 75(2): 247 - 260. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. H. Patel, Y. M. Tsutsumi, B. P. Head, I. R. Niesman, M. Jennings, Y. Horikawa, D. Huang, A. L. Moreno, P. M. Patel, P. A. Insel, et al. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1 FASEB J, May 1, 2007; 21(7): 1565 - 1574. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Martinson, M. P. Hans, G.-D. David, and A. M. Elizabeth Readers' choice: Hot papers downloaded in 2006 Cardiovasc Res, March 1, 2007; 73(4): 619 - 622. [Full Text] [PDF] |
||||
![]() |
G. Bkaily, P. D'Orleans-Juste, and D. Jacques A New Paradigm: Calcium Independent and Caveolae Internalization Dependent Release of Nitric Oxide by the Endothelial Nitric Oxide Synthase Circ. Res., October 13, 2006; 99(8): 793 - 794. [Full Text] [PDF] |
||||
![]() |
I. Fleming Segregation and integration: Roles played by caveolae and caveolins in the cardiovascular system Cardiovasc Res, March 1, 2006; 69(4): 784 - 787. [Full Text] [PDF] |
||||









