Copyright © 2005, European Society of Cardiology
Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: A temporal and spatial window
aMolecular and Vascular Biology and Center for Transgene Technology and Gene Therapy, University of Leuven, Belgium
bExperimental and Molecular Cardiology/CARIM, University of Maastricht, Netherlands
* Corresponding author. Experimental and Molecular Cardiology Laboratory/CARIM, Department of Cardiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands. Tel.: +31 43 3882950; fax: +31 43 3871055. Email address: s.heymans{at}cardio.unimaas.nl
The post-myocardial infarction wound repair process involves temporarily overlapping phases that include inflammation, formation of granulation tissue, scar formation, and overall left ventricle (LV) remodelling. The myocardial extracellular matrix (ECM) plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in wound repair post-myocardial infarction (MI). The main proteolytic system involved in the degradation of the ECM in the heart is the matrix metalloproteinase (MMPs) system. The present review will focus on the importance of the unique temporal and spatial window of MMPs and their inhibitors (TIMPs) within the different wound healing phases post-MI. It summarizes (1) the MMP/TIMP levels at different time points post-MI, (2) the alterations seen in post-MI healing in genetically modified mice, and (3) the effects and limitations of therapeutic MMP-inhibition post-MI.
KEYWORDS Infarction; Matrix metalloproteinases (MMPs); Extracellular matrix; Remodelling; Transgenic animal models
Time for primary review 18 days
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