Copyright © 2005, European Society of Cardiology
Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): A critical player in the development of atherosclerosis and related disorders
aDepartments of Internal Medicine and Physiology and Biophysics, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States
bUniversity of Rome Tor Vergata, Rome, Italy
* Corresponding author. Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot 532, Little Rock, AR 72205, United States. Tel.: +1 501 686 6724. Email address: MehtaJL{at}uams.edu
LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by angiotensin II, endothelin, cytokines, and shear stress, all participants in atherosclerosis. This receptor is upregulated in the arteries of hypertensive, dyslipidemic, and diabetic animals. Upregulation of LOX-1 has been identified in atherosclerotic arteries of several animal species and humans, not only on the endothelial lining, but also in the neovasculature of the atherosclerotic plaque, and this receptor is often co-localized with apoptotic cells. Recent studies show upregulation of LOX-1 in the ischemic-reperfused myocardium. LOX-1 inhibition is associated with attenuation of atherosclerosis and associated ischemic injury. LOX-1 may be a novel, exciting target for drug therapy.
KEYWORDS Lipids receptors; LOX-1; Oxidised LDL
Time for primary review 17 days
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
M. D. Mattaliano, C. Huard, W. Cao, A. A. Hill, W. Zhong, R. V. Martinez, D. C. Harnish, J. E. Paulsen, and H. H. Shih LOX-1-dependent transcriptional regulation in response to oxidized LDL treatment of human aortic endothelial cells Am J Physiol Cell Physiol, June 1, 2009; 296(6): C1329 - C1337. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. J. Kim, H. Moradi, J. Yuan, K. Norris, and N. D. Vaziri Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney Am J Physiol Renal Physiol, June 1, 2009; 296(6): F1297 - F1306. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Eichhorn, G. Muller, A. Leuner, T. Sawamura, U. Ravens, and H. Morawietz Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet Cardiovasc Res, June 1, 2009; 82(3): 493 - 502. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. H. Shih, S. Zhang, W. Cao, A. Hahn, J. Wang, J. E. Paulsen, and D. C. Harnish CRP is a novel ligand for the oxidized LDL receptor LOX-1 Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1643 - H1650. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Li and J. L. Mehta Intracellular Signaling of LOX-1 in Endothelial Cell Apoptosis Circ. Res., March 13, 2009; 104(5): 566 - 568. [Full Text] [PDF] |
||||
![]() |
J. Lu, J.-H. Yang, A. R. Burns, H.-H. Chen, D. Tang, J. P. Walterscheid, S. Suzuki, C.-Y. Yang, T. Sawamura, and C.-H. Chen Mediation of Electronegative Low-Density Lipoprotein Signaling by LOX-1: A Possible Mechanism of Endothelial Apoptosis Circ. Res., March 13, 2009; 104(5): 619 - 627. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Martinez-Miguel, V. Raoch, C. Zaragoza, J. M. Valdivielso, M. Rodriguez-Puyol, D. Rodriguez-Puyol, and S. Lopez-Ongil Endothelin-converting enzyme-1 increases in atherosclerotic mice: potential role of oxidized low density lipoproteins J. Lipid Res., March 1, 2009; 50(3): 364 - 375. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. D. N'Guessan, F. Riediger, K. Vardarova, S. Scharf, J. Eitel, B. Opitz, H. Slevogt, W. Weichert, A. C. Hocke, B. Schmeck, et al. Statins Control Oxidized LDL-Mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells Arterioscler. Thromb. Vasc. Biol., March 1, 2009; 29(3): 380 - 386. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. SUN, D. R. MAUERHAN, G. S. FIRESTEIN, B. J. LOEFFLER, E. N. HANLEY, and H. E. GRUBER Telomerase Transduced Osteoarthritis Fibroblast-Like Synoviocytes Display a Distinct Gene Expression Profile J Rheumatol, January 1, 2009; 36(1): 141 - 155. [Abstract] [Full Text] [PDF] |
||||
![]() |
M Ethier-Chiasson, J-C Forest, Y Giguere, A Masse, C Marseille-Tremblay, E Levy, and J Lafond Modulation of placental protein expression of OLR1: implication in pregnancy-related disorders or pathologies Reproduction, October 1, 2008; 136(4): 491 - 502. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. E. Brinkley, N. Kume, H. Mitsuoka, M. D. Brown, D. A. Phares, R. E. Ferrell, T. Kita, and J. M. Hagberg Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels Exp Physiol, September 1, 2008; 93(9): 1085 - 1090. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Hu, A. Dandapat, L. Sun, M. R. Marwali, N. Inoue, F. Sugawara, K. Inoue, Y. Kawase, K.-i. Jishage, H. Suzuki, et al. Modulation of Angiotensin II-Mediated Hypertension and Cardiac Remodeling by Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Deletion Hypertension, September 1, 2008; 52(3): 556 - 562. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. D. Frohlich Excitement of Clinical Investigation: New Basic Mechanisms of Action After Drug Introduction Hypertension, September 1, 2008; 52(3): 465 - 466. [Full Text] [PDF] |
||||
![]() |
H. Satoh, E. Kiyota, Y. Terasaki, T. Sawamura, K. Takagi, H. Mizuta, and M. Takeya Expression and Localization of Lectin-like Oxidized Low-density Lipoprotein Receptor-1 (LOX-1) in Murine and Human Placentas J. Histochem. Cytochem., August 1, 2008; 56(8): 773 - 784. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Hu, A. Dandapat, L. Sun, J. Chen, M. R. Marwali, F. Romeo, T. Sawamura, and J. L. Mehta LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet Cardiovasc Res, July 15, 2008; 79(2): 287 - 293. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. C. B. Tan, S. W. M. Shiu, Y. Wong, L. Leng, and R. Bucala Soluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitus J. Lipid Res., July 1, 2008; 49(7): 1438 - 1444. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Hu, A. Dandapat, L. Sun, J. A. Khan, Y. Liu, P. L. Hermonat, and J. L. Mehta Regulation of TGF{beta}1-mediated Collagen Formation by LOX-1: Studies Based on Forced Overexpression of TGF{beta}1 in Wild-Type and Lox-1 J. Biol. Chem., April 18, 2008; 283(16): 10226 - 10231. [Abstract] [Full Text] [PDF] |
||||












