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Cardiovascular Research 2006 69(1):272-279; doi:10.1016/j.cardiores.2005.07.009
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Copyright © 2005, European Society of Cardiology

Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts

Jun-ichi Suzukia,*, Masahito Ogawaa, Yuko M. Sagesakab and Mitsuaki Isobea

aDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
bCentral Research Institute, Ito-en Co., 21 Mekami, Sagara, Haibara, Shizuoka 421-0516, Japan

* Corresponding author. Tel.: +81 3 5803 5951; fax: +81 3 5803 0133. Email address: jsuzuki.cvm{at}tmd.ac.jp

Objective: Tea catechins have many biological functions; these effects are induced by the suppression of several inflammatory factors. However, effects of catechins on cardiac allograft rejection have not been well investigated.

Methods and results: To test the hypothesis that catechins can attenuate ventricular remodeling and graft arterial diseases (GAD) in cardiac rejection, we orally administered catechins to murine cardiac recipients. We analyzed the mechanisms using immunohistochemistry, RNase protection, gel mobility shift, and cell proliferation assays. Although severe myocardial cell infiltration, fibrosis, and GAD with enhancement of inflammatory factors were observed in untreated class II mismatch allografts at day 60, catechins attenuated these changes with altered Th1/Th2 cytokine balance and suppressed NF-{kappa}B activation and cell proliferation.

Conclusion: Catechins are potent agents for the suppression of chronic rejection because they are critically involved in the suppression of proinflammatory signaling pathways.

KEYWORDS Cardiac transplantation; Rejection; Artery; Inflammation; Polyphenol; Mice

Time for primary review 21 days


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