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Cardiovascular Research 2005 67(4):647-654; doi:10.1016/j.cardiores.2005.04.020
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Copyright © 2005, European Society of Cardiology

Endothelin receptor-A blockade decreases ventricular arrhythmias after myocardial infarction in rats

Giannis G. Baltogiannisa, Dimitrios G. Tsalikakisb, Agathokleia C. Mitsia, Konstantinos E. Hatzistergosc, Dimitrios Elaiopoulosa, Dimitrios I. Fotiadisb, Zenon S. Kyriakidesd and Theofilos M. Kolettisa,*

aDepartment of Cardiology, University of Ioannina, 1 University Avenue, 45110 Ioannina, Greece
bDepartment of Computer Sciences, University of Ioannina, 1 University Avenue, 45110 Ioannina, Greece
cDepartment of Pathology, University of Ioannina, 1 University Avenue, 45110 Ioannina, Greece
dDepartment of Cardiology, Hellenic Red Cross Hospital, 27 Venizelou Street, 17123 Athens, Greece

* Corresponding author. Tel.: +30 265 1097533; fax: +30 265 1097017. Email address: thkolet{at}cc.uoi.gr

Objective: Endothelin-1 (ET-1) production increases during acute myocardial infarction (MI) and may contribute to the genesis of ventricular tachycardia (VT) and ventricular fibrillation (VF). However, the antiarrhythmic effects of ET-1 receptor blockade, examined shortly after MI, have been debated. In the present study, we examined the effects of such treatment on VT/VF during the first 24 h post-MI.

Methods: Thirty-five Wistar rats (223 ± 22 g) were randomly allocated to either the ET-1 receptor-A (ETA) antagonist BQ-123 (0.4 mg/kg, BQ-123 group, n = 17), or normal saline (control group, n = 18) and were subjected to coronary artery ligation. A single-lead electrocardiogram was continuously recorded for 24 h post-MI, using an implanted telemetry system, and episodes of VT/VF were analyzed. Monophasic action potential (MAP) recordings were obtained from the left (LV) and right (RV) ventricular epicardium at baseline, 5 min after treatment and 24 h post-MI.

Results: There were 15.94 ± 19.35 episodes/h/rat of VT/VF in the control group and 1.66 ± 2.22 in the BQ-123 group (p = 0.010), resulting in a lower (p = 0.030) arrhythmic mortality in treated animals. The mean episode duration was 7.40 ± 7.16 s for the control group and 2.30 ± 1.37 s for the BQ-123 group (p = 0.011). The maximum decrease in VT/VF was observed during the 1st, 5th and 6th hours post-MI. In the control group, LV MAP duration increased 24 h post-MI, displaying an increased beat-to-beat variation, but remained unchanged in the BQ-123 group.

Conclusion: Acute ETA blockade reduces the incidence of VT/V F during the first 24-h post-MI in the rat, through a decrease in the dispersion of repolarization.

KEYWORDS Arrhythmia (mechanisms); Endothelins; Infarction

Time for primary review 17 days


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