Copyright © 2005, European Society of Cardiology
Sodium channels as macromolecular complexes: Implications for inherited arrhythmia syndromes
Department of Pharmacology, The University of Michigan, 1301 MSRB III, Box 0632, 1150 W. Medical Center Dr. Ann Arbor, MI 48109-0632, United States
* Corresponding author. Tel.: +1 734 936 3050; fax: +1 734 763 4450. Email address: lisom{at}umich.edu
Mutations in cardiac ion channels and their auxiliary subunits can lead to life-threatening cardiac arrhythmias. In recent years it has become apparent that ion channels are part of large, multi-protein complexes, comprising not only the ion channels and their auxiliary subunits, but also components of the cytoskeleton, regulatory kinases and phosphatases, trafficking proteins, extracellular matrix proteins, and possibly even other ion channels. Disruption of any member of a particular ion channel complex has the potential to disrupt the function of the associated channels, resulting in paroxysmal disease. Understanding the molecular composition of individual ion channel signaling complexes in heart may yield important insights into the molecular basis of cardiac arrhythmias and may suggest novel therapeutic approaches to treatment of these life-threatening conditions.
KEYWORDS Cardiac myocytes; Channel physiology; Sodium channel; Auxilliary subunits; Cell adhesion molecules
Time for primary review 26 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. M. Cordeiro, M. Mazza, R. Goodrow, N. Ulahannan, C. Antzelevitch, and J. M. Di Diego Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H154 - H162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yang, C. F. Browning, H. Hallaq, L. Yermalitskaya, J. Esker, M. R. Hall, A. J. Link, A.-J. L. Ham, M. J. McGrath, C. A. Mitchell, et al. Four and a half LIM protein 1: a partner for KCNA5 in human atrium Cardiovasc Res, June 1, 2008; 78(3): 449 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Maltsev, V. Reznikov, N. A. Undrovinas, H. N. Sabbah, and A. Undrovinas Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1597 - H1608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Brackenbury, T. H. Davis, C. Chen, E. A. Slat, M. J. Detrow, T. L. Dickendesher, B. Ranscht, and L. L. Isom Voltage-Gated Na+ Channel {beta}1 Subunit-Mediated Neurite Outgrowth Requires Fyn Kinase and Contributes to Postnatal CNS Development In Vivo J. Neurosci., March 19, 2008; 28(12): 3246 - 3256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wu, S. L. Yong, C. Fan, Y. Ni, S. Yoo, T. Zhang, X. Zhang, C. A. Obejero-Paz, H.-J. Rho, T. Ke, et al. Identification of a New Co-factor, MOG1, Required for the Full Function of Cardiac Sodium Channel Nav1.5 J. Biol. Chem., March 14, 2008; 283(11): 6968 - 6978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Abriel Roles and regulation of the cardiac sodium channel Nav1.5: Recent insights from experimental studies Cardiovasc Res, December 1, 2007; 76(3): 381 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Casini, H. L. Tan, Z. A. Bhuiyan, C. R. Bezzina, P. Barnett, E. Cerbai, A. Mugelli, A. A.M. Wilde, and M. W. Veldkamp Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation Cardiovasc Res, December 1, 2007; 76(3): 418 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fatkin, R. Otway, and J. I. Vandenberg Genes and Atrial Fibrillation: A New Look at an Old Problem Circulation, August 14, 2007; 116(7): 782 - 792. [Full Text] [PDF]
|
|
|
|
|
|
A. Medeiros-Domingo, T. Kaku, D. J. Tester, P. Iturralde-Torres, A. Itty, B. Ye, C. Valdivia, K. Ueda, S. Canizales-Quinteros, M. T. Tusie-Luna, et al. SCN4B-Encoded Sodium Channel 4 Subunit in Congenital Long-QT Syndrome Circulation, July 10, 2007; 116(2): 134 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cordeiro, H. Barajas-Martinez, K. Hong, E. Burashnikov, R. Pfeiffer, A.-M. Orsino, Y. S. Wu, D. Hu, J. Brugada, P. Brugada, et al. Compound Heterozygous Mutations P336L and I1660V in the Human Cardiac Sodium Channel Associated With the Brugada Syndrome Circulation, November 7, 2006; 114(19): 2026 - 2033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Lopez-Santiago, M. Pertin, X. Morisod, C. Chen, S. Hong, J. Wiley, I. Decosterd, and L. L. Isom Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. J. Neurosci., July 26, 2006; 26(30): 7984 - 7994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Bezzina, A. A.M. Wilde, and D. M. Roden The molecular genetics of arrhythmias Cardiovasc Res, August 15, 2005; 67(3): 343 - 346. [Full Text] [PDF]
|
|