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Cardiovascular Research 2005 67(3):438-447; doi:10.1016/j.cardiores.2005.04.021
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Copyright © 2005, European Society of Cardiology

Functional genomics of cardiac ion channel genes

Sophie Demolombe, Céline Marionneau, Sabrina Le Bouter, Flavien Charpentier and Denis Escande*

l'institut du thorax, INSERM U533, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes cedex, France

* Corresponding author. Tel.: +33 240 41 29 49; fax: +33 240 41 29 50. Email address: denis.escande{at}nantes.inserm.fr

Ion channels are an ensemble of specialized membrane proteins that act in concert to create and modulate the electrical activity of many excitable cells, including cardiac myocytes. Following completion of the sequencing of various genomes, including that of the human, the complete repertoire of ion channel genes has been elucidated for different species. How transcripts issued from this gene collection are expressed and modulated in relation to variable physiological and pathological situations is the subject of functional or physiological genomics. Specialized microarrays (IonChips) comprising probes for the ensemble of ion channel and regulatory genes were developed as an alternative to whole-genome DNA chips. Physiological genomics of cardiac ion channel genes is a growing field that, in combination with genetics, should markedly increase our comprehension of the molecular mechanisms leading to arrhythmias.

KEYWORDS Ion channel expression; DNA microarrays; Molecular remodeling; Arrhythmias

Time for primary review 27 days


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