Copyright © 2005, European Society of Cardiology
Interferon-
and atherosclerosis: Pro- or anti-atherogenic?
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, U.K.
* Corresponding author. Tel./fax: +44 29 20876753. Email address: Ramji{at}cardiff.ac.uk
Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-
(IFN-) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN- regulates the function and properties of all the cell types in the vessel wall. The precise role of IFN- in atherogenesis is complex, with both pro- and anti-atherogenic actions being identified. This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN- signaling.
KEYWORDS Atherosclerosis; Cytokines; Foam cell; Inflammation; Interferon-
Time for primary review 20 days
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