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Cardiovascular Research 2005 66(2):222-232; doi:10.1016/j.cardiores.2005.02.009
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Copyright © 2005, European Society of Cardiology

Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition

Fabio Di Lisaa,c,* and Paolo Bernardib,c

aDipartimento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, 35121 Padova, Italy
bDipartimento di Scienze Biomediche Sperimentali, Università di Padova, Viale G. Colombo 3, 35121 Padova, Italy
cIstituto di Neuroscienze del CNR, Università di Padova, Viale G. Colombo 3, 35121 Padova, Italy

* Corresponding author. Dipartimento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, 35121 Padova, Italy. Tel.: +39 49 8276132; fax: +39 49 8073310. Email address: dilisa{at}civ.bio.unipd.it

Mitochondria have been suggested to be causally linked to age-related alterations through respiratory chain dysfunction and formation of reactive oxygen species, leading to damage of mitochondrial DNA. Impaired biosynthesis of respiratory chain and ATP synthase subunits encoded by mitochondrial genes would set up a vicious cycle contributing to the aging process. Mitochondria are also involved in the increased susceptibility to ischemic injury observed in aged hearts, a process where the mitochondrial permeability transition pore (PTP) may play a role. Here, we analyze (i) the possible mechanisms through which PTP opening might contribute to age-related myocardial alterations; (ii) the available evidence of an increased probability of PTP opening in mitochondria isolated from aged tissues; (iii) the current methodological limitations that complicate the elucidation of causal relationships between PTP opening, mitochondrial dysfunction, and myocardial aging.

KEYWORDS Aging; Mitochondria; Permeability transition; Reactive oxygen species; Ischemia

Time for primary review 20 days


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