Copyright © 2004, European Society of Cardiology
Structural and functional characterisation of cardiac fibroblasts
aUniversity Laboratory of Physiology, Oxford, OX1 3PT, UK
bDepartment of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, United States
* Corresponding author. Fax: +44 1865 272554. Email address: peter.kohl{at}physiol.ox.ac.uk
Cardiac fibroblasts form one of the largest cell populations, in terms of cell numbers, in the heart. They contribute to structural, biochemical, mechanical and electrical properties of the myocardium. Nonetheless, they are often disregarded by in vivo and in vitro studies into cardiac function. This review summarizes our understanding of fibroblast origin and identity, their structural organization and role in myocardial architecture, as well as functional aspects related to cell signalling and electro-mechanical function in the heart.
KEYWORDS Connective tissue; Myocardium; Remodelling; Gap junction; Heart
Time for primary review 27 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. M. Pedrotty, R. Y. Klinger, R. D. Kirkton, and N. Bursac Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes Cardiovasc Res, June 27, 2009; (2009) cvp164v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Banerjee, J. W. Fuseler, A. R. Intwala, and T. A. Baudino IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1694 - H1704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Manso, S.-M. Kang, S. V. Plotnikov, I. Thievessen, J. Oh, H. E. Beggs, and R. S. Ross Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H627 - H638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Huang, C. Yang, Y. Wang, Y. Liao, and K. Huang PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR{gamma} in cardiac fibroblasts Cardiovasc Res, January 1, 2009; 81(1): 98 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Totlandsdal, M. Refsnes, T. Skomedal, J.-B. Osnes, P. E. Schwarze, and M. Lag Particle-Induced Cytokine Responses in Cardiac Cell Cultures--the Effect of Particles versus Soluble Mediators Released by Particle-Exposed Lung Cells Toxicol. Sci., November 1, 2008; 106(1): 233 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cabo Modulation of impulse propagation by fibroblasts Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H1992 - H1993. [Full Text] [PDF]
|
|
|
|
|
|
V. P. Singh, K. M. Baker, and R. Kumar Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1675 - H1684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Fahrenbach, R. Mejia-Alvarez, and K. Banach The relevance of non-excitable cells for cardiac pacemaker function J. Physiol., December 1, 2007; 585(2): 565 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K Parker and D. E Ingber Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering Phil Trans R Soc B, August 29, 2007; 362(1484): 1267 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Podgorska, K. Kocbuch, M. Grden, A. Szutowicz, and T. Pawelczyk Reduced ability to release adenosine by diabetic rat cardiac fibroblasts due to altered expression of nucleoside transporters J. Physiol., October 1, 2006; 576(1): 179 - 189. [Abstract] [Full Text] [PDF]
|
|