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Cardiovascular Research 2004 63(3):391-402; doi:10.1016/j.cardiores.2004.03.011
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

Network integration of the adrenergic system in cardiac hypertrophy

Liza Barki-Harrington, Cinzia Perrino and Howard A Rockman*

Departments of Medicine, Cell Biology and Molecular Genetics, Duke University Medical Center, DUMC 3104 226 CARL Building, Research Drive, Durham, NC 27710 USA

* Corresponding author. Tel.: +1-919-668-2520; fax: +1-919-668-2524. Email address: h.rockman{at}duke.edu

Adrenergic receptors play a pivotal role in regulating cardiac function in response to a constantly changing environment. Altered {alpha} and β adrenergic receptor signaling in vivo is associated with cardiac hypertrophy and failure. This review focuses on the different roles of adrenergic receptors in regulating cardiac function under normal and pathological conditions. Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure.

KEYWORDS Adrenergic receptors; Heart failure; Cardiac hypertrophy

Time for primary review 16 days


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