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Cardiovascular Research 2004 63(3):373-380; doi:10.1016/j.cardiores.2004.04.031
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence

Giulio Selvetellaa, Emilio Hirschb, Antonella Nottea, Guido Taroneb and Giuseppe Lembo*,a,c

aDepartment of Angiocardioneurology, I.R.C.C.S. "Neuromed", "La Sapienza" University of Rome, 86077 Pozzilli (IS), Italy
bDepartment of Genetics, Biology, and Biochemistry, Turin University, 10126 Turin, Italy
cDepartment of Experimental Medicine and Pathology, "La Sapienza" University of Rome, Italy

* Corresponding author. Department of Angiocardioneurology, I.R.C.C.S. "Neuromed", "La Sapienza" University of Rome, Molise Section, Località Camerelle, 86077 Pozzilli (IS), Italy. Tel.: +39-0865-915244; fax: 39-0865-927575. Email address: lembo{at}neuromed.it

Myocardial hypertrophy is a response of cardiac muscle to altered conditions of haemodynamic overload caused by a large number of physiological and pathological conditions. Traditionally, it has been considered a beneficial mechanism. However, sustained hypertrophy has been associated with a significant increase in the risk of cardiovascular disease and mortality. Actually, many researchers are trying to understand whether left ventricular hypertrophy is a ‘good’ mechanism to stimulate or a ‘bad’ process to prevent. In this review we investigate the most common biochemical signaling pathways involved in the hypertrophic response to identify the precise role, either ‘adaptive’ or ‘maladaptive’, of each molecular pathway. Delinealing intracellular signaling pathways involved in the different aspects of cardiac hypertrophy will permit future improvements in the signaling that controls beneficial growth.

KEYWORDS Left ventricular hypertrophy; Signaling; Transgenic mice; Pressure overload

Time for primary review 25 days


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