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Cardiovascular Research 2004 63(1):149-154; doi:10.1016/j.cardiores.2004.02.017
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

Transendothelial lipoprotein exchange and microalbuminuria

Jan Skov Jensen*,a,b, Bo Feldt-Rasmussena, Kurt Svarre Jensena,c, Peter Clausena, Henrik Scharlingb and Børge Grønne Nordestgaardb,c

aDepartment of Nephrology and Endocrinology P., The National University Hospital, Copenhagen, Denmark
bThe Copenhagen City Heart Study, Bispebjerg University Hospital, Copenhagen, Denmark
cDepartment of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark

*Corresponding author. Department of Cardiology P., Gentofte University Hospital, Niels Andersensvej 65, 2900 Hellerup, Denmark. Tel.: +45-39777-450; fax: +45-39777-117. Email address: jsje{at}c.dk

Objective: Microalbuminuria associates with increased risk of atherosclerosis in individuals without diabetes. We hypothesized that transendothelial lipoprotein exchange is elevated among such individuals, possibly explaining increased intimal lipoprotein accumulation and thus atherosclerosis. Methods: Using an in vivo isotope technique, transendothelial exchange of low density lipoprotein (LDL) was measured in 77 non-diabetic individuals. Autologous 131-iodinated LDL was reinjected intravenously, and the 1-h fractional escape rate was calculated as index of transendothelial exchange. Results: There was no difference in transendothelial LDL exchange between subjects with microalbuminuria versus normoalbuminuria (mean (95% confidence interval) 3.8%/h (3.3–4.3%/h) versus 4.2%/h (3.7–4.7%/h); P=0.33). In contrast, there was a positive correlation between transendothelial LDL exchange and (logarithmically transformed) plasma insulin: β=0.6 (95% CI: 0.1–1.1); R=0.22; P<0.05. This correlation was independent of age, sex, blood pressure, plasma concentration of lipoproteins, LDL size, body mass index, plasma volume, and use of medicine, and it was unlikely caused by altered hepatic LDL receptor expression, or glycosylation of LDL. Conclusion: In non-diabetic individuals, transendothelial LDL exchange is not associated with microalbuminuria, but possibly with hyperinsulinemia.

KEYWORDS Atherosclerosis; Capillary permeability; Insulin resistance; Lipoproteins; Lipid metabolism; Microalbuminuria

Time for primary review 20 days


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