Skip Navigation

Cardiovascular Research 2004 62(2):299-308; doi:10.1016/j.cardiores.2004.02.010
© 2004 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gros, D.
Right arrow Articles by Théveniau-Ruissy, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gros, D.
Right arrow Articles by Théveniau-Ruissy, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2004, European Society of Cardiology

Genetically modified mice: tools to decode the functions of connexins in the heart—new models for cardiovascular research

Daniel Gros*, Laurent Dupays1, Sébastien Alcoléa2, Sonia Meysen, Lucile Miquerol and Magali Théveniau-Ruissy

Laboratoire de Génétique et Physiologie du Développement (UMR CNRS 6545), Campus de Luminy, Case 907, Institut de Biologie du Développement de Marseille, Université de la Méditerranée, Marseilles cedex 13288, France

* Corresponding author. Tel.: +33-491-26-97-32; fax: +33-491-26-97-26. Email address: gros{at}ibdm.univ-mrs.fr

It has long been known that gap junctions are required for the propagation of electrical impulse in the heart. A good deal later, the connexins (Cxs), which are probably exclusive components of the junctional channels that constitute the gap junctions, were identified. More recently, the in vivo functions of cardiac Cxs have been investigated by the analysis of genetically modified mice. These studies have confirmed that Cxs are involved in cardiac impulse conduction, and, unexpectedly, in heart morphogenesis. In addition, cardiac abnormalities described in mice genetically modified for Cx genes, and those observed in certain human cardiac diseases, have been proven to be similar.

KEYWORDS Connexins; Arrhythmia (mechanisms); Conduction (block); Sudden death; Developmental biology

1 Present address: National Institute for Medical Research, Mill Hill, London, UK.

2 Present address: Laboratoire de Physiopathologie et Pharmacologie Cellulaire et Moléculaire (U INSERM 533), Nantes, France.

Time for primary review 20 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.