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Cardiovascular Research 2004 61(3):512-521; doi:10.1016/j.cardiores.2003.11.028
© 2004 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Role of clinical pathologies in myocardial injury following ischaemia and reperfusion

Manuel Galiñanes* and Alan G Fowler

Integrative Human Cardiovascular Physiology and Cardiac Surgery Unit, Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK

* Corresponding author. Tel.: +44-116-2563032; fax: +44-116-2502449. mg50{at}le.ac.uk

The myocardial injury that occurs following a period of ischaemia and reperfusion is well recognised and the underlying mechanisms have been extensively investigated in healthy myocardial tissues; however, the influence of the risk factors associated with cardiovascular diseases on ischaemia/reperfusion injury remains unclear. In this article, the present knowledge on how clinical pathologies such as diabetes, hypercholesterolaemia, hypertension, myocardial hypertrophy and heart failure may influence ischaemia/reperfusion injury of the heart and the potential mechanisms involved are reviewed.

KEYWORDS Reperfusion injury; Diabetes; Hypercholesterolaemia; Hypertension; Hypertrophy; Heart failure


Time for primary review 15 days


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