© 2004 by European Society of Cardiology
Copyright © 2003, European Society of Cardiology
Role of clinical pathologies in myocardial injury following ischaemia and reperfusion
Integrative Human Cardiovascular Physiology and Cardiac Surgery Unit, Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK
* Corresponding author. Tel.: +44-116-2563032; fax: +44-116-2502449. mg50{at}le.ac.uk
The myocardial injury that occurs following a period of ischaemia and reperfusion is well recognised and the underlying mechanisms have been extensively investigated in healthy myocardial tissues; however, the influence of the risk factors associated with cardiovascular diseases on ischaemia/reperfusion injury remains unclear. In this article, the present knowledge on how clinical pathologies such as diabetes, hypercholesterolaemia, hypertension, myocardial hypertrophy and heart failure may influence ischaemia/reperfusion injury of the heart and the potential mechanisms involved are reviewed.
KEYWORDS Reperfusion injury; Diabetes; Hypercholesterolaemia; Hypertension; Hypertrophy; Heart failure