Skip Navigation

Cardiovascular Research 2004 61(3):437-447; doi:10.1016/j.cardiores.2003.11.033
© 2004 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Chi, N. C
Right arrow Articles by Karliner, J. S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chi, N. C
Right arrow Articles by Karliner, J. S
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2003, European Society of Cardiology

Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factors

Neil C Chi and Joel S Karliner*

Cardiology Section, Medical Service, Veterans Affairs Medical Center, University of California, 4150 Clement St., San Francisco, CA 94121, USA
Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, CA, USA

* Corresponding author. Cardiology Section, Medical Service, Veterans Affairs Medical Center, University of California, 4150 Clement St., San Francisco, CA 94121, USA. Tel.: +1-415-221-4810x3171; fax: +1-415-750-6950. joel.karliner{at}med.va.gov

During the past several years much new evidence has accumulated regarding the molecular and biochemical mechanisms underlying cardiac responses to hypoxia and to ischemia/reperfusion injury. Studies have involved cell culture, and ex vivo and in vivo preparations. This review focuses on regulation of two transcription factors that are thought to be important in these processes, hypoxia-inducible factor1{alpha} (HIF-1{alpha}) and heat shock factor (HSF). Both of these molecules are expressed acutely and chronically in response to hypoxia and ischemia/reperfusion, and both have numerous targets that comprise part of integrated response to ischemic injury aimed at promoting cell survival. Emphasis is placed on new mechanisms of action that regulate HIF-1{alpha}, HSF, and heat shock proteins as key responses to hypoxia and ischemia, and possible approaches to therapy based on these data are discussed.

KEYWORDS Hypoxia; Reoxygenation; Ischemia/reperfusion; Gene regulation; Transcription factor; Preconditioning; Hypoxia-inducible factor (HIF)

Time for primary review 35 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.