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Cardiovascular Research 2003 60(2):228-234; doi:10.1016/S0008-6363(03)00541-8
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Intrauterine undernutrition—renal and vascular origin of hypertension

Maria do Carmo Pinho Franco*,a, Dorothy Nigroa, Zuleica B Fortesa, Rita C.A Tostesa, Maria Helena C Carvalhoa, Sandra Regina Rodrigues Lucasb, Guiomar Nascimento Gomesc, Terezila Machado Coimbrac and Frida Zaladek Gilc

aLaboratório de Hipertensão, Departamento de Farmacologia, Instituto de Ciências Biomédicas I (ICB-I), Universidade de São Paulo, 05508-900, Av. Prof. Lineu Prestes, 1524, sala 205, São Paulo, SP, Brazil
bDisciplina de Embriologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil
cDisciplina de Fisiologia Renal e Termometabologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil

*Corresponding author. Tel./fax: +55-11-3091-7317. Email address: mdcfranco{at}yahoo.com

Objective: A large number of clinical and experimental studies supports the hypothesis that intrauterine undernutrition is an important determinant of hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. In this review, the renal and vascular repercussions of maternal undernutrition are emphasized, and the physiopatologic mechanisms discussed. The origin of hypertension is detailed based upon the findings of kidney functional parameters and endothelium function studies. A working model linking hypertension to intrauterine undernutrition is proposed.

KEYWORDS Hypertension; Renal function; Nitric oxide; Endothelial function; Low birth weight

Time for primary review 29 days


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