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Cardiovascular Research 2003 60(1):136-140; doi:10.1016/S0008-6363(03)00355-9
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Preprocedural serum levels of acute-phase reactants and prognosis after percutaneous coronary intervention

Braim M. Rahela,*, Frank L.J. Visserenb, Maarten-Jan Suttorpa, Thijs H.W. Plokkera, Johannes C. Keldera, Bartelt M. de Jonghc, K.Paul Bouterd and Rob J.A. Diepersloote

aDepartment of Cardiology, Heart Lung Center Utrecht, Location: St Antonius Hospital Nieuwegein, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands
bDepartment of Internal and Vascular Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands
cDepartment of Microbiology, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands
dDepartment of Internal Medicine, Jeroen Bosch Hospital, Den Bosch, The Netherlands
eDepartment of Microbiology, Diakonessen Hospital Utrecht, Utrecht, The Netherlands

*Corresponding author. Tel.: +31-30-609-2278; fax: +31-30-609-2277. Email address: b.rahel{at}antonius.net

Objective: In this study we evaluate the value of baseline concentrations of acute-phase reactants on prognosis after percutaneous coronary intervention (PCI). Methods: Blood samples were drawn immediately before PCI to measure baseline concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), lipoprotein(a) (Lp(a)), and fibrinogen. Follow-up data were collected at 8 months. Repeat PCI, CABG, myocardial infarction, and death were recorded as major adverse clinical events (MACE). Furthermore the recurrence of angina pectoris was noted. Results: The study included 600 consecutive patients after a successful PCI. Sixty-four percent of the patients were stented. The mean age was 61.6 years and 68.9% were male. CRP levels were significantly higher in patients who were to have repeat angina as compared with those who were not (P = 0.0322). IL-6 levels were not correlated with angina or MACE. Lp(a) and fibrinogen concentrations were both significantly related to MACE (P = 0.0337 and P = 0.0253, respectively). Conclusion: Our study clearly supports the role of inflammation in restenosis after PCI as measured in statistically higher levels of Lp(a) and fibrinogen in patients with MACE and CRP in patients with repeat angina.

KEYWORDS Angioplasty; Coronary disease; Endothelial function; Infection/inflammation; Restenosis

Time for primary review 25 days.


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