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Cardiovascular Research 2003 59(4):812-823; doi:10.1016/S0008-6363(03)00516-9
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Matrix metalloproteinases

A review of their structure and role in acute coronary syndrome

Charles B Jones, David C Sane and David M Herrington*

Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA

dherring{at}wfubmc.edu

* Corresponding author. Tel.: +1-336-716-4950; fax: +1-336-716-9188.

Objective: To summarize the structure, function, and regulation of matrix metalloproteinases (MMPs) and to review the literature to date on their potential role in the pathogenesis of acute coronary syndromes. Methods: A recursive strategy starting with a Medline Search for primary articles in the last decade, followed by identification of additional articles of interest among the cited literature in the primary articles, followed by identification of additional articles of interest cited in the secondary articles. Results: MMPs play a central role in many fundamental processes in human health and disease. In vitro evidence suggests that MMP activity may facilitate atherosclerosis, plaque destabilization, and platelet aggregation. Limited evidence from clinical studies supports a role of MMPs in the development of acute coronary syndromes. Conclusions: MMP activity likely contributes to the development of acute coronary syndromes and may be an important therapeutic target for future drug development.

KEYWORDS Acute coronary syndromes; Matrix metalloproteinases


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