Skip Navigation

Cardiovascular Research 2003 59(3):745-754; doi:10.1016/S0008-6363(03)00479-6
© 2003 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Merkus, D.
Right arrow Articles by Duncker, D. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Merkus, D.
Right arrow Articles by Duncker, D. J
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2003, European Society of Cardiology

Contribution of endothelin and its receptors to the regulation of vascular tone during exercise is different in the systemic, coronary and pulmonary circulation

Daphne Merkusa,*, Birgit Houwelinga, Amran Mirzaa, Frans Boomsmab, Anton H van den Meirackerb and Dirk J Dunckera

aExperimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
bInternal Medicine, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

d.merkus{at}erasmusmc.nl

* Corresponding author. Tel.: +31-10-408-8025; fax: +31-10-408-9494.

Objectives: Exercise-induced vasodilation is thought to be mediated through various vasodilator substances, but blunting the influence of vasoconstrictors such as ET may also play a role. However, the role of ET and its receptors in the regulation of systemic, pulmonary and coronary vascular resistance is incompletely understood. The aim of this study was to identify the contribution of ET-1 through the ETA and ETB receptors to the regulation of tone in the systemic, coronary and pulmonary beds at rest and during exercise. Methods: Ten chronically instrumented swine were studied while running on a treadmill before and after ETA blockade (EMD122946) or ETAB blockade (tezosentan). Results: At rest, EMD122946 resulted in vasodilation in the coronary and systemic circulation, evidenced by a decrease in coronary and systemic vascular resistance and an increase in coronary and mixed venous O2-saturation. These effects waned during exercise. The effect of tezosentan on the systemic vasculature was similar to that of EMD122946, whereas it was smaller in the coronary circulation. EMD122946 had no effect on the pulmonary vasculature, whereas tezosentan decreased pulmonary resistance but only during exercise. Conclusions: ET exerts a constrictor influence on the coronary and systemic circulation through the ETA-receptor, which decreases during exercise thereby contributing to metabolic vasodilation. ET exerts a tonic vasodilator influence on coronary resistance vessels through the ETB-receptor. Finally, ET exerts an ETB-mediated constrictor influence in the pulmonary vasculature during exercise.

KEYWORDS Metabolic vasodilation; Coronary blood flow; Peripheral resistance; Pulmonary resistance


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
D. J. Duncker and R. J. Bache
Regulation of Coronary Blood Flow During Exercise
Physiol Rev, July 1, 2008; 88(3): 1009 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. J. de Beer, O. Sorop, D. A. Pijnappels, D. H. Dekkers, F. Boomsma, J. M. J. Lamers, D. J. Duncker, and D. Merkus
Integrative control of coronary resistance vessel tone by endothelin and angiotensin II is altered in swine with a recent myocardial infarction
Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2069 - H2077.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
O. Sorop, D. Merkus, V. J. de Beer, B. Houweling, A. Pistea, E. O. McFalls, F. Boomsma, H. M. van Beusekom, W. J. van der Giessen, E. VanBavel, et al.
Functional and Structural Adaptations of Coronary Microvessels Distal to a Chronic Coronary Artery Stenosis
Circ. Res., April 11, 2008; 102(7): 795 - 803.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.