Skip Navigation

Cardiovascular Research 2003 58(3):510-517; doi:10.1016/S0008-6363(03)00331-6
© 2003 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Peschar, M.
Right arrow Articles by Prinzen, F. W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peschar, M.
Right arrow Articles by Prinzen, F. W
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2003, European Society of Cardiology

Absence of reverse electrical remodeling during regression of volume overload hypertrophy in canine ventricles

Maaike Peschara, Kevin Vernooya, Ward Y.R Vanagta, Robert S Renemana, Marc A Vosb and Frits W Prinzena,*

aDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
bDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

frits.prinzen{at}fys.unimaas.nl

* Corresponding author. Tel.: +31-43-388-1080; fax: +31-43-3884166.

Objective: Ventricular hypertrophy predisposes for cardiac arrhythmias, presumably due to prolongation of repolarization (electrical remodeling). The temporal relation between the development of hypertrophy and electrical remodeling, as well as their reversibility upon restoration of normal load, however, are poorly understood. This was investigated in the present study using volume overload hypertrophy induced by atrio-ventricular (AV) block and normalization of load by pacing. Methods: Dogs were subjected to either 16 weeks of AV-block (CAVB group, n = 9) or 8 weeks of AV-block followed by 8 weeks of right ventricular (RV) pacing at physiological heart rate (CAVB+PACE group, n = 9). Results: Left ventricular (LV) mass (2D-echocardiography) increased after 8 weeks of AV-block to ~30% above baseline and returned to 10±14% after 8 weeks of pacing. QT-time (surface ECG) also increased after AV-block. However, 8 weeks of pacing did not decrease QT and QTc-time (c=corrected for heart rate), neither during physiological pacing nor during temporary pacing at 100 beats/min. Lack of reverse electrical remodeling was confirmed by the absence of changes in LV and RV action potential duration (monophasic action potentials) at week 8 and 16. Conclusions: In volume overload hypertrophy due to AV-block, structural and electrical remodeling develop in parallel but restoration of physiological heart rate causes dissociation between reverse structural remodeling and reverse electrical remodeling.

KEYWORDS Remodeling; Repolarization; Hypertrophy; Bradycardia


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
S. K.G. Winckels, M. B. Thomsen, P. Oosterhoff, A. Oros, J. D.M. Beekman, N. J.M. Attevelt, L. Kretzers, and M. A. Vos
High-Septal Pacing Reduces Ventricular Electrical Remodeling and Proarrhythmia in Chronic Atrioventricular Block Dogs
J. Am. Coll. Cardiol., August 28, 2007; 50(9): 906 - 913.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Suto, W. Zhu, A. Chan, and G. J. Gross
IKr and IKs remodeling differentially affects QT interval prolongation and dynamic adaptation to heart rate acceleration in bradycardic rabbits
Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1782 - H1788.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. P. Gray, M. A. Turner, D. J. Sheridan, and C. H. Fry
The role of angiotensin receptor-1 blockade on electromechanical changes induced by left ventricular hypertrophy and its regression
Cardiovasc Res, February 1, 2007; 73(3): 539 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
K. Vernooy, X. A.A.M. Verbeek, M. Peschar, H. J.G.M. Crijns, T. Arts, R. N.M. Cornelussen, and F. W. Prinzen
Left bundle branch block induces ventricular remodelling and functional septal hypoperfusion
Eur. Heart J., January 1, 2005; 26(1): 91 - 98.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
E. Perrier, B.-G. Kerfant, N. Lalevee, P. Bideaux, M. F. Rossier, S. Richard, A. M. Gomez, and J.-P. Benitah
Mineralocorticoid Receptor Antagonism Prevents the Electrical Remodeling That Precedes Cellular Hypertrophy After Myocardial Infarction
Circulation, August 17, 2004; 110(7): 776 - 783.
[Abstract] [Full Text] [PDF]

Home page
 J CARDIOVASC PHARMACOL THERHome page
S. Wasson, H. K. Reddy, and M. L. Dohrmann
Current Perspectives of Electrical Remodeling and Its Therapeutic Implications
Journal of Cardiovascular Pharmacology and Therapeutics, April 1, 2004; 9(2): 129 - 144.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
H. K. Reddy, S. Wasson, S. K.G. Koshy, and R. Komatireddy
Structural correlates of electrical remodeling in ventricular hypertrophy
Cardiovasc Res, June 1, 2003; 58(3): 495 - 497.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.