Skip Navigation

Cardiovascular Research 2003 58(2):336-350; doi:10.1016/S0008-6363(03)00254-2
© 2003 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Dowell, J. D.
Right arrow Articles by Field, L. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dowell, J. D.
Right arrow Articles by Field, L. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2003, European Society of Cardiology

Myocyte and myogenic stem cell transplantation in the heart

Joshua D. Dowell, Michael Rubart, Kishore B.S. Pasumarthi, Mark H. Soonpaa and Loren J. Field*

Wells Center for Pediatric Research and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202-5225, USA

ljfield{at}iupui.edu

* Corresponding author. Herman B Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Room 2600, 702 Barnhill Dr., Indianapolis, IN 46202-5225, USA. Tel.: +1-317-274-5085; fax: +1-317-274-5378.

Cellular transplantation is emerging as a potential mechanism with which to augment myocyte number in diseased hearts. To date a number of cell types have been shown to successfully engraft into the myocardium, including fetal, neonatal, and embryonic stem cell-derived cardiomyocytes, skeletal myoblasts, and stem cells with apparent cardiomyogenic potential. Here we provide a review of studies wherein myocytes or stem cells with myogenic potential have been transplanted into the heart. In addition, issues pertaining to the tracking and functional consequences of cell transplantation are discussed.

KEYWORDS Cellular transplantation; Cardiomyocytes; Skeletal myoblasts; Stem cells; Heart failure


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. Madonna, Y.-J. Geng, and R. De Caterina
Adipose Tissue-Derived Stem Cells: Characterization and Potential for Cardiovascular Repair
Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1723 - 1729.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
R J Hassink, H Nakajima, H O Nakajima, P A Doevendans, and L J Field
Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction
Heart, July 15, 2009; 95(14): 1159 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. A.J. Chamuleau, E. van Belle, and P. A. Doevendans
Enhancing cardiac stem cell differentiation into cardiomyocytes
Cardiovasc Res, June 1, 2009; 82(3): 385 - 387.
[Full Text] [PDF]

Home page
 Arch OphthalmolHome page
V. Enzmann, E. Yolcu, H. J. Kaplan, and S. T. Ildstad
Stem Cells as Tools in Regenerative Therapy for Retinal Degeneration
Arch Ophthalmol, April 1, 2009; 127(4): 563 - 571.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Menasche, O. Alfieri, S. Janssens, W. McKenna, H. Reichenspurner, L. Trinquart, J.-T. Vilquin, J.-P. Marolleau, B. Seymour, J. Larghero, et al.
The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial: First Randomized Placebo-Controlled Study of Myoblast Transplantation
Circulation, March 4, 2008; 117(9): 1189 - 1200.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
T. R. Payne, H. Oshima, M. Okada, N. Momoi, K. Tobita, B. B. Keller, H. Peng, and J. Huard
A Relationship Between Vascular Endothelial Growth Factor, Angiogenesis, and Cardiac Repair After Muscle Stem Cell Transplantation Into Ischemic Hearts
J. Am. Coll. Cardiol., October 23, 2007; 50(17): 1677 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Y. Li, P. Atmaca-Sonmez, C. L. Schanie, S. T. Ildstad, H. J. Kaplan, and V. Enzmann
Endogenous Bone Marrow Derived Cells Express Retinal Pigment Epithelium Cell Markers and Migrate to Focal Areas of RPE Damage
Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4321 - 4327.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Buggisch, B. Ateghang, C. Ruhe, C. Strobel, S. Lange, M. Wartenberg, and H. Sauer
Stimulation of ES-cell-derived cardiomyogenesis and neonatal cardiac cell proliferation by reactive oxygen species and NADPH oxidase
J. Cell Sci., March 1, 2007; 120(5): 885 - 894.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
M Saha, R Zbinden, S R Redwood, and M S Marber
Stem cells to repair the broken heart: much ado about nothing?
Heart, December 1, 2006; 92(12): 1717 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
P. Menasche, M. Desnos, and A. A. Hagege
Myoblast transplantation during cardiac surgery
Eur. Heart J. Suppl., December 1, 2006; 8(suppl_H): H52 - H56.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. W. van Laake, R. Hassink, P. A. Doevendans, and C. Mummery
Heart repair and stem cells
J. Physiol., December 1, 2006; 577(2): 467 - 478.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Oettgen
Cardiac Stem Cell Therapy: Need for Optimization of Efficacy and Safety Monitoring
Circulation, July 25, 2006; 114(4): 353 - 358.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Nakajima, H. O. Nakajima, K. Dembowsky, K. B.S. Pasumarthi, and L. J. Field
Cardiomyocyte Cell Cycle Activation Ameliorates Fibrosis in the Atrium
Circ. Res., January 6, 2006; 98(1): 141 - 148.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. E. Murry, L. J. Field, and P. Menasche
Cell-Based Cardiac Repair: Reflections at the 10-Year Point
Circulation, November 15, 2005; 112(20): 3174 - 3183.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. A. Laflamme, J. Gold, C. Xu, M. Hassanipour, E. Rosler, S. Police, V. Muskheli, and C. E. Murry
Formation of Human Myocardium in the Rat Heart from Human Embryonic Stem Cells
Am. J. Pathol., September 1, 2005; 167(3): 663 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
H. Piao, T.-J. Youn, J.-S. Kwon, Y.-H. Kim, J.-W. Bae, Bora-Sohn, D.-W. Kim, M.-C. Cho, M.-M. Lee, and Y.-B. Park
Effects of bone marrow derived mesenchymal stem cells transplantation in acutely infarcting myocardium
Eur J Heart Fail, August 1, 2005; 7(5): 730 - 738.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. E. Davis, P. C.H. Hsieh, A. J. Grodzinsky, and R. T. Lee
Custom Design of the Cardiac Microenvironment With Biomaterials
Circ. Res., July 8, 2005; 97(1): 8 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. Formigli, F. Francini, A. Tani, R. Squecco, D. Nosi, L. Polidori, S. Nistri, L. Chiappini, V. Cesati, A. Pacini, et al.
Morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture is favored by direct cell-cell contacts and relaxin treatment
Am J Physiol Cell Physiol, April 1, 2005; 288(4): C795 - C804.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. C. Wollert and H. Drexler
Clinical Applications of Stem Cells for the Heart
Circ. Res., February 4, 2005; 96(2): 151 - 163.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
B. Dawn and R. Bolli
Bone marrow cells for cardiac regeneration: the quest for the protagonist continues
Cardiovasc Res, February 1, 2005; 65(2): 293 - 295.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. M. Regula, M. J. Rzeszutek, D. Baetz, C. Seneviratne, and L. A. Kirshenbaum
Therapeutic opportunities for cell cycle re-entry and cardiac regeneration
Cardiovasc Res, December 1, 2004; 64(3): 395 - 401.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
K. Matsuura, H. Wada, T. Nagai, Y. Iijima, T. Minamino, M. Sano, H. Akazawa, J. D. Molkentin, H. Kasanuki, and I. Komuro
Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle
J. Cell Biol., October 25, 2004; 167(2): 351 - 363.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
S M Selkirk
Gene therapy in clinical medicine
Postgrad. Med. J., October 1, 2004; 80(948): 560 - 570.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. A. Narmoneva, R. Vukmirovic, M. E. Davis, R. D. Kamm, and R. T. Lee
Endothelial Cells Promote Cardiac Myocyte Survival and Spatial Reorganization: Implications for Cardiac Regeneration
Circulation, August 24, 2004; 110(8): 962 - 968.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Kanno, P. K. M. Kim, K. Sallam, J. Lei, T. R. Billiar, and L. L. Shears II
Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells
PNAS, August 17, 2004; 101(33): 12277 - 12281.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. S. Maniar, B. P. Cupps, D. D. Potter, P. Moustakidis, C. J. Camillo, C. M. Chu, M. K. Pasque, and T. M. Sundt III
Ventricular function after coronary artery bypass grafting: Evaluation by magnetic resonance imaging and myocardial strain analysis
J. Thorac. Cardiovasc. Surg., July 1, 2004; 128(1): 76 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. M. Regula and L. A. Kirshenbaum
Breaking Down Cell-Cycle Barriers in the Adult Heart
Circ. Res., June 25, 2004; 94(12): 1524 - 1526.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Nakajima, H. O. Nakajima, S.-C. Tsai, and L. J. Field
Expression of Mutant p193 and p53 Permits Cardiomyocyte Cell Cycle Reentry After Myocardial Infarction in Transgenic Mice
Circ. Res., June 25, 2004; 94(12): 1606 - 1614.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. D. Vanderlaan, G. Y. Oudit, and P. H. Backx
Electrophysiological Profiling of Cardiomyocytes in Embryonic Bodies Derived From Human Embryonic Stem Cells: Therapeutic Implications
Circ. Res., July 11, 2003; 93(1): 1 - 3.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Rubart, K. B.S. Pasumarthi, H. Nakajima, M. H. Soonpaa, H. O. Nakajima, and L. J. Field
Physiological Coupling of Donor and Host Cardiomyocytes After Cellular Transplantation
Circ. Res., June 13, 2003; 92(11): 1217 - 1224.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.