Skip Navigation

Cardiovascular Research 2003 57(2):388-394; doi:10.1016/S0008-6363(02)00705-8
© 2003 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Xu, Y.
Right arrow Articles by Davidge, S. T
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, Y.
Right arrow Articles by Davidge, S. T
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2003, European Society of Cardiology

Estrogen modulation of left ventricular remodeling in the aged heart

Yi Xu, Ivan A Arenas, Stephen J Armstrong and Sandra T Davidge*

Departments of Obstetrics/Gynecology and Physiology, Perinatal Research Centre, University of Alberta, 220 Heritage Medical Research Centre, Edmonton, AB, Canada T6G 2S2

* Corresponding author. Tel.: +1-780-492-1864; fax: +1-780-492-1308. sandra.davidge{at}ualberta.ca

Objective: To investigate the effects of estrogen on left ventricle (LV) mass and collagen deposition, and on the expression of receptors for estrogen (ER{alpha}, ERβ) and Ang II (AT2R, AT1R) in the heart of aged female rats. Methods: Aged (~12 months old) intact (n=7), ovariectomized plus placebo (OVX, n=7), and estrogen-replaced (E2, n=6) as well as young (~3 months old, n=4) female Sprague–Dawley rats were used in this study. After 1 month of treatment, the left ventricular weight/body weight ratio (LVW/BW), changes in myosin heavy chain expression (MHC), matrix metalloproteinase (MMP)-2 activity, the collagen I/III ratio, and the expression of ERs and Ang II receptors in the LV were evaluated. Results: In aged rats, OVX increased LVW/BW associated with a higher expression of β-MHC isoform, increased collagen I/III ratio, and decreased MMP-2 activity compared to intact rats. Furthermore, the OVX group had a decrease in ERs {alpha} and β as well as AT2R but an increase in AT1R expression. Estrogen replacement prevented the effects of ovariectomy on heart remodeling as well as increased further expression of ERβ and decreased AT1R expression. Conclusion: Removal of ovarian hormones increased LV remodeling in the aged rat, which could be attenuated by estrogen replacement. Moreover, regulation of Ang II receptor expression could be a mechanism by which estrogen may modulate heart remodeling.

KEYWORDS Aging; Hormones; Hypertrophy; Receptors; Remodeling


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CirculationHome page
W. Lieb, V. Xanthakis, L. M. Sullivan, J. Aragam, M. J. Pencina, M. G. Larson, E. J. Benjamin, and R. S. Vasan
Longitudinal Tracking of Left Ventricular Mass Over the Adult Life Course: Clinical Correlates of Short- and Long-Term Change in the Framingham Offspring Study
Circulation, June 23, 2009; 119(24): 3085 - 3092.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Ikeda, K.-i. Aihara, S. Yoshida, T. Sato, S. Yagi, T. Iwase, Y. Sumitomo, T. Ise, K. Ishikawa, H. Azuma, et al.
Androgen-Androgen Receptor System Protects against Angiotensin II-Induced Vascular Remodeling
Endocrinology, June 1, 2009; 150(6): 2857 - 2864.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
V. Ricchiuti, C. G Lian, E. M Oestreicher, L. Tran, J. R Stone, T. Yao, E. W Seely, G. H Williams, and G. K Adler
Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats
J. Endocrinol., January 1, 2009; 200(1): 75 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. R. Bell, E. R. Porrello, C. E. Huggins, S. B. Harrap, and L. M. D. Delbridge
The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy
Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1514 - H1522.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.