© 2003 by European Society of Cardiology
Copyright © 2003, European Society of Cardiology
Estrogen modulation of left ventricular remodeling in the aged heart
Departments of Obstetrics/Gynecology and Physiology, Perinatal Research Centre, University of Alberta, 220 Heritage Medical Research Centre, Edmonton, AB, Canada T6G 2S2
* Corresponding author. Tel.: +1-780-492-1864; fax: +1-780-492-1308. sandra.davidge{at}ualberta.ca
Objective: To investigate the effects of estrogen on left ventricle (LV) mass and collagen deposition, and on the expression of receptors for estrogen (ER
, ERβ) and Ang II (AT2R, AT1R) in the heart of aged female rats. Methods: Aged (
12 months old) intact (n=7), ovariectomized plus placebo (OVX, n=7), and estrogen-replaced (E2, n=6) as well as young (3 months old, n=4) female Sprague–Dawley rats were used in this study. After 1 month of treatment, the left ventricular weight/body weight ratio (LVW/BW), changes in myosin heavy chain expression (MHC), matrix metalloproteinase (MMP)-2 activity, the collagen I/III ratio, and the expression of ERs and Ang II receptors in the LV were evaluated. Results: In aged rats, OVX increased LVW/BW associated with a higher expression of β-MHC isoform, increased collagen I/III ratio, and decreased MMP-2 activity compared to intact rats. Furthermore, the OVX group had a decrease in ERs and β as well as AT2R but an increase in AT1R expression. Estrogen replacement prevented the effects of ovariectomy on heart remodeling as well as increased further expression of ERβ and decreased AT1R expression. Conclusion: Removal of ovarian hormones increased LV remodeling in the aged rat, which could be attenuated by estrogen replacement. Moreover, regulation of Ang II receptor expression could be a mechanism by which estrogen may modulate heart remodeling.
KEYWORDS Aging; Hormones; Hypertrophy; Receptors; Remodeling
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Ostadal, I. Netuka, J. Maly, J. Besik, and I. Ostadalova Gender Differences in Cardiac Ischemic Injury and Protection--Experimental Aspects Experimental Biology and Medicine, September 1, 2009; 234(9): 1011 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Lieb, V. Xanthakis, L. M. Sullivan, J. Aragam, M. J. Pencina, M. G. Larson, E. J. Benjamin, and R. S. Vasan Longitudinal Tracking of Left Ventricular Mass Over the Adult Life Course: Clinical Correlates of Short- and Long-Term Change in the Framingham Offspring Study Circulation, June 23, 2009; 119(24): 3085 - 3092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ikeda, K.-i. Aihara, S. Yoshida, T. Sato, S. Yagi, T. Iwase, Y. Sumitomo, T. Ise, K. Ishikawa, H. Azuma, et al. Androgen-Androgen Receptor System Protects against Angiotensin II-Induced Vascular Remodeling Endocrinology, June 1, 2009; 150(6): 2857 - 2864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Ricchiuti, C. G Lian, E. M Oestreicher, L. Tran, J. R Stone, T. Yao, E. W Seely, G. H Williams, and G. K Adler Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats J. Endocrinol., January 1, 2009; 200(1): 75 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Bell, E. R. Porrello, C. E. Huggins, S. B. Harrap, and L. M. D. Delbridge The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1514 - H1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Gardner, G. L. Brower, T. G. Voloshenyuk, and J. S. Janicki Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogens Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H198 - H204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Md. S. Bhuiyan, N. Shioda, and K. Fukunaga Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1606 - E1614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Deschepper and B. Llamas Hypertensive Cardiac Remodeling in Males and Females: From the Bench to the Bedside Hypertension, March 1, 2007; 49(3): 401 - 407. [Full Text] [PDF]
|
|
|
|
|
|
C. Hinojosa-Laborde and M. L. Lindsey Aging Modifies the Cardiac Response to Estrogen: A New Dimension to Hormone Replacement Therapy Hypertension, October 1, 2006; 48(4): 558 - 559. [Full Text] [PDF]
|
|
|
|
|
|
V. Jazbutyte, K. Hu, P. Kruchten, E. Bey, S. K.G. Maier, K.-H. Fritzemeier, K. Prelle, C. Hegele-Hartung, R. W. Hartmann, L. Neyses, et al. Aging Reduces the Efficacy of Estrogen Substitution to Attenuate Cardiac Hypertrophy in Female Spontaneously Hypertensive Rats Hypertension, October 1, 2006; 48(4): 579 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Arenas, S. J. Armstrong, Y. Xu, and S. T. Davidge Tumor Necrosis Factor-{alpha} and Vascular Angiotensin II in Estrogen-Deficient Rats Hypertension, September 1, 2006; 48(3): 497 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xu, S. J. Williams, D. O'Brien, and S. T. Davidge Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring FASEB J, June 1, 2006; 20(8): 1251 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Arenas, Y. Xu, and S. T. Davidge Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF-{alpha} antagonism Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1259 - H1263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xu, I. A. Arenas, S. J. Armstrong, W. C. Plahta, H. Xu, and S. T. Davidge Estrogen improves cardiac recovery after ischemia/reperfusion by decreasing tumor necrosis factor-{alpha} Cardiovasc Res, March 1, 2006; 69(4): 836 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Booth, N. R. Obeid, and B. R. Lucchesi Activation of estrogen receptor-{alpha} protects the in vivo rabbit heart from ischemia-reperfusion injury Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2039 - H2047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Chancey, J. D. Gardner, D. B. Murray, G. L. Brower, and J. S. Janicki Modulation of cardiac mast cell-mediated extracellular matrix degradation by estrogen Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H316 - H321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. F. Koehler, L. A. Helguero, L.-A. Haldosen, M. Warner, and J.-A. Gustafsson Reflections on the Discovery and Significance of Estrogen Receptor {beta} Endocr. Rev., May 1, 2005; 26(3): 465 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Dean, J. Tan, E. R. O'Brien, and F. H. H. Leenen 17{beta}-Estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R759 - R766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Forster, S. Kietz, K. Hultenby, M. Warner, and J.-A. Gustafsson Characterization of the ER{beta}-/-mouse heart PNAS, September 28, 2004; 101(39): 14234 - 14239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Larkin, B. C. Frank, R. M. Gaspard, I. Duka, H. Gavras, and J. Quackenbush Cardiac transcriptional response to acute and chronic angiotensin II treatments Physiol Genomics, July 8, 2004; 18(2): 152 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xu, S. J. Armstrong, I. A. Arenas, D. J. Pehowich, and S. T. Davidge Cardioprotection by chronic estrogen or superoxide dismutase mimetic treatment in the aged female rat Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H165 - H171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Young and R. L. Stouffer Gonadotropin and Steroid Regulation of Matrix Metalloproteinases and Their Endogenous Tissue Inhibitors in the Developed Corpus Luteum of the Rhesus Monkey During the Menstrual Cycle Biol Reprod, January 1, 2004; 70(1): 244 - 252. [Abstract] [Full Text] [PDF]
|
|