© 2003 by European Society of Cardiology
Copyright © 2003, European Society of Cardiology
Myocardial blood flow in patients with hibernating myocardium
MRC Clinical Sciences Centre and National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
* Corresponding author. Tel.: +44-208-383-3186; fax: +44-208-383-3742. paolo.camici{at}csc.mrc.ac.uk
The debate on whether resting myocardial blood flow (MBF) to hibernating myocardium is reduced or not has attracted a lot of interest and has contributed to stimulate new research on heart failure in patients with coronary artery disease (CAD). Positron emission tomography with oxygen-15 labeled water (H215O) or nitrogen-13 labeled ammonia (13NH3) has been used for the absolute quantification of regional MBF in human hibernating myocardium. When hibernating myocardium is properly identified, i.e. a dysfunctional segment subtended by a stenotic coronary artery that improves function upon reperfusion, the following conclusions can be reached based on the available literature: (a) in the majority of these studies resting MBF in hibernating myocardium is not different from either flow in remote tissue in the same patient or MBF in normal healthy volunteers; (b) a reduction in MBF of 
20% compared to MBF in remote myocardium or age matched normal subjects has been demonstrated in a minority of truly hibernating segments; (c) hibernating myocardium is characterized by a severely impaired coronary flow reserve which improves after revascularization in parallel with contractile function. Thus, the pathophysiology of hibernation in humans is more complex than initially postulated. The recent evidence that repetitive ischemia in patients with coronary artery disease can be cumulative and lead to more severe and prolonged stunning, lends further support to the hypothesis that, at least initially, stunning and hibernation are two facets of the same coin.
KEYWORDS Blood flow; Coronary circulation; Hibernation
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Neglia and A. L'Abbate Myocardial Perfusion Reserve in Ischemic Heart Disease J. Nucl. Med., February 1, 2009; 50(2): 175 - 177. [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Duncker and R. J. Bache Regulation of Coronary Blood Flow During Exercise Physiol Rev, July 1, 2008; 88(3): 1009 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Sorop, D. Merkus, V. J. de Beer, B. Houweling, A. Pistea, E. O. McFalls, F. Boomsma, H. M. van Beusekom, W. J. van der Giessen, E. VanBavel, et al. Functional and Structural Adaptations of Coronary Microvessels Distal to a Chronic Coronary Artery Stenosis Circ. Res., April 11, 2008; 102(7): 795 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Flevari, G. Theodorakis, I. Paraskevaidis, F. Kolokathis, A. Kostopoulou, D. Leftheriotis, C. Kroupis, E. Livanis, and D. T. Kremastinos Coronary and peripheral blood flow changes following biventricular pacing and their relation to heart failure improvement. Europace, January 1, 2006; 8(1): 44 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Selvanayagam, M. Jerosch-Herold, I. Porto, D. Sheridan, A. S.H. Cheng, S. E. Petersen, N. Searle, K. M. Channon, A. P. Banning, and S. Neubauer Resting Myocardial Blood Flow Is Impaired in Hibernating Myocardium: A Magnetic Resonance Study of Quantitative Perfusion Assessment Circulation, November 22, 2005; 112(21): 3289 - 3296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Abbate, R. Bussani, G. G.L. Biondi-Zoccai, D. Santini, A. Petrolini, F. D. Giorgio, F. Vasaturo, S. Scarpa, A. Severino, G. Liuzzo, et al. Infarct-related artery occlusion, tissue markers of ischaemia, and increased apoptosis in the peri-infarct viable myocardium Eur. Heart J., October 1, 2005; 26(19): 2039 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Kaufmann and P. G. Camici Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications J. Nucl. Med., January 1, 2005; 46(1): 75 - 88. [Full Text] [PDF]
|
|
|
|
|
|
C. Depre, S.-J. Kim, A. S. John, Y. Huang, O. E. Rimoldi, J. R. Pepper, G. D. Dreyfus, V. Gaussin, D. J. Pennell, D. E. Vatner, et al. Program of Cell Survival Underlying Human and Experimental Hibernating Myocardium Circ. Res., August 20, 2004; 95(4): 433 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Knaapen, L. M.C. van Campen, C. C. de Cock, M. J.W. Gotte, C. A. Visser, A. A. Lammertsma, and F. C. Visser Effects of Cardiac Resynchronization Therapy on Myocardial Perfusion Reserve Circulation, August 10, 2004; 110(6): 646 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Milei, C. G. Fraga, D. R. Grana, R. Ferreira, and G. Ambrosio Ultrastructural evidence of increased tolerance of hibernating myocardium to cardioplegic ischemia-reperfusion injury J. Am. Coll. Cardiol., June 16, 2004; 43(12): 2329 - 2336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P G Camici Myocardial hibernation and heart failure: introduction Heart, February 1, 2004; 90(2): 136 - 136. [Full Text] [PDF]
|
|
|
|
|
|
P G Camici Hibernation and heart failure Heart, February 1, 2004; 90(2): 141 - 143. [Full Text] [PDF]
|
|
|
|
|
|
M. Zoghi and S. Nalbantgil Electrical stunning and hibernation: suggestion of new terms for short- and long-term cardiac memory Europace, January 1, 2004; 6(5): 418 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Bianco, E. Tadamura, M. Yamamuro, S. Kubo, M. Mamede, and R. Sciagra Absolute Quantitation of Myocardial Blood Flow After Nitroglycerin and Ischemic Cardiomyopathy with a Low Ejection Fraction J. Nucl. Med., November 1, 2003; 44(11): 1872 - 1873. [Full Text]
|
|