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Cardiovascular Research 2002 54(3):528-538; doi:10.1016/S0008-6363(01)00551-X
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

A review of the carotid and femoral intima-media thickness as an indicator of the presence of peripheral vascular disease and cardiovascular risk factors

Koon-Sung Chenga, Dimitri P. Mikhailidisb, George Hamiltona and Alexander M. Seifaliana,*

aVascular Haemodynamic Unit, University Department of Surgery, Royal Free and University College Medical School, University College London and The Royal Free Hospital, Pond Street, London NW3 2QG, UK
bDepartment of Clinical Biochemistry, Royal Free and University College Medical School, University College London, London, UK

a.seifalian{at}rfc.ucl.ac.uk

* Corresponding author. Tel.: +44-20-7830-2901 (direct) or +44-20-7794-0500 Ext. 3936; fax: +44-20-7431-4528

Peripheral vascular disease (PVD) is a common condition often associated with cardiovascular risk factors and events. With the aid of B-mode ultrasound scanning, evidence is emerging that these risk factors and events are significantly related to an increased carotid and femoral intima-media thickness (IMT). More importantly, treatment of these risk factors is associated with a decrease or a diminished progression of the IMT, paralleled by a reduction in cardiovascular events and an improvement in the symptoms associated with PVD. This evidence is particularly strong for lipid lowering therapy. Additional predictors of cardiovascular risk like the IMT, could now influence the decision to intervene with medication.

KEYWORDS Arteries; Atherosclerosis; Epidemiology; Ultrasound


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