© 2002 by European Society of Cardiology
Copyright © 2002, European Society of Cardiology
Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?
aDepartment of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street E., Montreal, Quebec, Canada H1T 1C8
bDepartment of Medicine, University of Montreal, Montreal, Quebec, Canada
cDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
* Present address: Montreal Heart Institute, Research Center, University of Montreal, 5000 Belanger Street E., Montreal, Quebec, Canada H1T 1C8. Tel.: +1-514-376-3330x3990; fax: +1-514-376-1355 nattel{at}icm.umontreal.ca
Atrial fibrillation (AF) is a very common clinical problem, and presently available treatment options are suboptimal. A tremendous amount has been learned over the past 10 years about the atrial substrates that support sustained AF at the tissue, ionic and molecular levels. This understanding of the fundamental mechanisms underlying AF has opened up a variety of new, rationally-based therapeutic approaches. The present paper reviews what is known about the mechanistic substrates that lead to AF and discusses the potential therapeutic consequences.
KEYWORDS Antiarrhythmic agents; Arrhythmia (mechanisms); Gene expression; Ion channels; Remodeling
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