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Cardiovascular Research 2002 54(2):280-286; doi:10.1016/S0008-6363(02)00225-0
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

Transgenic and knockout mouse models of atrial arrhythmias

Jeffrey E. Olgin* and Sander Verheule

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA

* Corresponding author. Indiana University School of Medicine, Noyes Pavilion, Room E410, Methodist Hospital, 1800 North Capital, Indianapolis, IN 46202, USA. Tel.: +1-317-962-0101; fax: +1-317-962-0100 jolgin{at}iupui.edu

While much has been learned about atrial fibrillation from large animal models, many of these studies are correlative. Genetically-altered mouse models have provided much information about such genetic diseases as the long QT syndrome, but have to date not been utilized much to study atrial fibrillation. The ability to study the importance of a single gene product in pathophysiology make this a potentially powerful tool to understand the causal relationship of several proteins and the substrate for atrial fibrillation. In this manuscript we review the techniques available to study atrial electrophysiology and some of the genetically-altered mouse models that have implications for atrial fibrillation.

KEYWORDS Arrhythmia (mechanisms); Atrial function; Gene expression


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