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Cardiovascular Research 2002 54(1):16-24; doi:10.1016/S0008-6363(01)00516-8
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

Application of gene expression profiling to cardiovascular disease

P.A Henriksen and Y Kotelevtsev*

Division of Bio-Medical Sciences, Room 323a, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK

* Corresponding author. Tel.: +44-131-651-1194; fax: +44-131-650-6527 yuri.kotelevtsev{at}ed.ac.uk

The number of cardiovascular publications featuring gene expression profiling technologies is growing rapidly. This article introduces four profiling techniques; serial analysis of gene expression, differential display, subtractive hybridisation and DNA microarrays. Illustrations of their application towards cardiovascular research are given and their potential for gene discovery and improving our understanding of gene function is discussed.

KEYWORDS Gene expression; Sequence (DNA/RNA/prot)


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