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Cardiovascular Research 2002 53(3):538-549; doi:10.1016/S0008-6363(01)00388-1
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

Risk factors for coronary heart disease: implications of gender

Jeanine E Roeters van Lennepa, H.Tineke Westerveldb, D.Willem Erkelensb and Ernst E van der Walla,*

aDepartment of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
bDepartment of Internal Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands

* Corresponding author. Building 1, C5-P 28, PO Box 9600, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands. Tel.: +31-71-526-2038; fax: +31-71-524-8116 e.e.van_der_wall{at}lumc.nl

It has been recognized over the past years that women form a distinct subpopulation within patients with coronary heart disease. This phenomenon should be acknowledged in the management and in the assessment of coronary heart disease. Over the past years remarkable progress has been made concerning our knowledge of cardiovascular risk factors related to gender. For instance, diabetes, high density lipoproteins and triglycerides levels have been found to have a greater impact on coronary heart disease risk in women compared to men. On the other hand, evidence showing that lipoprotein (a) is a cardiovascular risk factor seems to be stronger in men than in women. For optimal treatment and prevention of coronary heart disease it is necessary to acknowledge that it is not self-evident that women and men show simular responses to risk factors or to treatment. This review article addresses the role of cardiovascular risk factors focusing on the differential impact they might have on men and women.

KEYWORDS Coronary disease; Epidemiology; Gender


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