© 2002 by European Society of Cardiology
Copyright © 2001, European Society of Cardiology
Is angiotensin II a proliferative factor of cardiac fibroblasts?
Laboratory of Cell Biology of Hypertension, Multidisciplinary Research Group in Hypertension of the Canadian Institutes of Health Research, Institut de recherches cliniques de Montréal (IRCM) and Université de Montréal, 110 Pine Avenue West, Montréal, Québec, Canada H2W 1R7
* Corresponding author. Tel.: +1-514-987-5613; fax: +1-514-987-5585 thibaug{at}ircm.qc.ca
Angiotensin II has been implicated as an important factor in cardiac remodeling, particularly in the development of pathological left ventricular hypertrophy. It is generally assumed that angiotensin II is able to alter the phenotype of cardiac myocytes and fibroblasts, and several experiments have suggested that this peptide can particularly affect the proliferation of cardiac fibroblasts. However, a review of the published results indicates that there is no evidence that angiotensin II can directly trigger mitogenesis through activation of the cyclin-dependent pathway. The observed proliferative effect might well be caused by stimulation of the synthesis of growth or inflammatory substances like platelet-derived growth factor and cytokines, by integrin activation due to secreted extracellular matrix proteins, or by a combination of these mechanisms. Angiotensin II thus appears to differentiate cardiac fibroblasts into a growth substance-secreting phenotype.
KEYWORDS Angiotensin; Connective tissue; Fibrosis; Growth factors; Remodeling
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H. Kvakan, M. Kleinewietfeld, F. Qadri, J.-K. Park, R. Fischer, I. Schwarz, H.-P. Rahn, R. Plehm, M. Wellner, S. Elitok, et al. Regulatory T Cells Ameliorate Angiotensin II-Induced Cardiac Damage Circulation, June 9, 2009; 119(22): 2904 - 2912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Pellieux, C. Montessuit, I. Papageorgiou, and R. Lerch Angiotensin II downregulates the fatty acid oxidation pathway in adult rat cardiomyocytes via release of tumour necrosis factor-{alpha} Cardiovasc Res, May 1, 2009; 82(2): 341 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lijnen Angiotensin II-Induced Proliferation of Neonatal and Adult Rat Cardiac Fibroblasts Hypertension, June 1, 2008; 51(6): e50 - e50. [Full Text] [PDF]
|
|
|
|
|
|
B. Burstein, E. Libby, A. Calderone, and S. Nattel Differential Behaviors of Atrial Versus Ventricular Fibroblasts: A Potential Role for Platelet-Derived Growth Factor in Atrial-Ventricular Remodeling Differences Circulation, April 1, 2008; 117(13): 1630 - 1641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Konhilas and L. A. Leinwand The Effects of Biological Sex and Diet on the Development of Heart Failure Circulation, December 4, 2007; 116(23): 2747 - 2759. [Full Text] [PDF]
|
|
|
|
|
|
R. J.A. Frost and S. Engelhardt A Secretion Trap Screen in Yeast Identifies Protease Inhibitor 16 as a Novel Antihypertrophic Protein Secreted From the Heart Circulation, October 16, 2007; 116(16): 1768 - 1775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Kumbar, A. VanBergen, C. Ocampo, S. Muangmingsuk, A. J. Griffin, and M. Gupta Adapter molecule DOC-2 is differentially expressed in pressure and volume overload hypertrophy and inhibits collagen synthesis in cardiac fibroblasts J Appl Physiol, May 1, 2007; 102(5): 2024 - 2032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kanamori, G. Takemura, Y. Li, H. Okada, R. Maruyama, T. Aoyama, S. Miyata, M. Esaki, A. Ogino, M. Nakagawa, et al. Inhibition of Fas-associated apoptosis in granulation tissue cells accompanies attenuation of postinfarction left ventricular remodeling by olmesartan Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2184 - H2194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Nykamp and E. E Winter Olmesartan Medoxomil-Induced Angioedema Ann. Pharmacother., March 1, 2007; 41(3): 518 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Baudino, W. Carver, W. Giles, and T. K. Borg Cardiac fibroblasts: friend or foe? Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1015 - H1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Westerkamp and S. E. Gordon Angiotensin-converting enzyme inhibition attenuates myonuclear addition in overloaded slow-twitch skeletal muscle Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1223 - R1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Lekgabe, H. Kiriazis, C. Zhao, Q. Xu, X. L. Moore, Y. Su, R. A.D. Bathgate, X.-J. Du, and C. S. Samuel Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats Hypertension, August 1, 2005; 46(2): 412 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hein Angiotensin II and cell-matrix adhesion: PKC{varepsilon} is essential Cardiovasc Res, July 1, 2005; 67(1): 6 - 8. [Full Text] [PDF]
|
|
|
|
|
|
D. H. Freed, R. H. Cunnington, A. L. Dangerfield, J. S. Sutton, and I. M.C. Dixon Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart Cardiovasc Res, March 1, 2005; 65(4): 782 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Otis, S. Campbell, M. D. Payet, and N. Gallo-Payet Angiotensin II Stimulates Protein Synthesis and Inhibits Proliferation in Primary Cultures of Rat Adrenal Glomerulosa Cells Endocrinology, February 1, 2005; 146(2): 633 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fairweather, S. Frisancho-Kiss, S. A. Yusung, M. A. Barrett, S. E. Davis, S. J.L. Gatewood, D. B. Njoku, and N. R. Rose Interferon-{gamma} Protects against Chronic Viral Myocarditis by Reducing Mast Cell Degranulation, Fibrosis, and the Profibrotic Cytokines Transforming Growth Factor-{beta}1, Interleukin-1{beta}, and Interleukin-4 in the Heart Am. J. Pathol., December 1, 2004; 165(6): 1883 - 1894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Maass, K. Ikeda, S. Oberdorf-Maass, S. K.G. Maier, and L. A. Leinwand Hypertrophy, Fibrosis, and Sudden Cardiac Death in Response to Pathological Stimuli in Mice With Mutations in Cardiac Troponin T Circulation, October 12, 2004; 110(15): 2102 - 2109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Samuel, E. N. Unemori, I. Mookerjee, R. A. D. Bathgate, S. L. Layfield, J. Mak, G. W. Tregear, and X.-J. Du Relaxin Modulates Cardiac Fibroblast Proliferation, Differentiation, and Collagen Production and Reverses Cardiac Fibrosis in Vivo Endocrinology, September 1, 2004; 145(9): 4125 - 4133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rosenkranz TGF-{beta}1 and angiotensin networking in cardiac remodeling Cardiovasc Res, August 15, 2004; 63(3): 423 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Porter, N. A. Turner, D. J. O'Regan, A. J. Balmforth, and S. G. Ball Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA Cardiovasc Res, March 1, 2004; 61(4): 745 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, H. Chen, A. Seth, and C. A. McCulloch Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1871 - H1881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Tian, J. Liu, P. Bitterman, and R. J. Bache Angiotensin II modulates nitric oxide-induced cardiac fibroblast apoptosis by activation of AKT/PKB Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1105 - H1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Manabe, T. Shindo, and R. Nagai Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy Circ. Res., December 13, 2002; 91(12): 1103 - 1113. [Abstract] [Full Text] [PDF]
|
|