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Cardiovascular Research 2002 53(1):9-11; doi:10.1016/S0008-6363(01)00519-3
© 2002 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

Two ways to feel the pressure: an endothelial Ca2+ entry channel with dual mechanosensitivity

Klaus Groschner*

Department of Pharmacology and Toxicology, Karl-Franzens-University Graz, Universitaetsplatz 2, A-8010 Graz, Austria

* Tel.: +43-316-380-5570; fax: +43-316-380-9890 klaus.groschner{at}kfunigraz.ac.at

One impressive function of the vascular endothelium is its ability to adjust the release of vasoactive mediators such as NO and PGI2 almost instantaneously to changes in blood flow or blood pressure. Besides this fast feedback response to hemodynamic alterations, the endothelium is subject to long-term adaptations that are crucial for prevention of pathological processes such as atherogenesis. Among the various signals that are sensed by endothelial cells, mechanical forces which arise from pulsatile blood flow are probably most important for fast as well as long-term control of blood vessel function by the endothelium.

KEYWORDS Vascular endothelium; Ca2+; Dual mechanosensitivity


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