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Cardiovascular Research 2001 51(3):489-494; doi:10.1016/S0008-6363(01)00238-3
© 2001 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

The role of the natriuretic peptides in the cardiovascular system

Toru Suzukia,*, Tsutomu Yamazakib and Yoshio Yazakic

aDepartment of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
bDepartment of Pharmacoepidemiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
cInternational Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan

* Corresponding author. Tel.: +81-3-3815-5411 ext. 33117; fax: +81-3-5800-8824 torusuzu-tky{at}umin.ac.jp

The discovery of the natriuretic peptide family was a breakthrough in modern cardiovascular physiology as it provided a direct link between the heart and the kidneys in the regulation of natriuresis. Along with vasopressin and the renin–angiotensin–aldosterone system, the natriuretic peptides comprise the key peptides on which our present understanding of neuroendocrine regulation of the cardiovascular system is based. Three natriuretic peptides have been identified; the A-type, B-type and C-type natriuretic peptides. The former two, the A- and B-type natriuretic peptides, function mainly in the cardiovascular system and comprise the cardiac natriuretic peptides. Together with our increased understanding of the neurohormonal regulation of the cardiovascular system in recent years, the discovery of the natriuretic peptide family was important in the establishment of the new field of cardiovascular endocrinology.

KEYWORDS Antihypertensive/diuretic agents; Hemodynamics; Hormones; Natriuretic peptide; Receptors


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