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Cardiovascular Research 2001 51(3):450-462; doi:10.1016/S0008-6363(01)00331-5
© 2001 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

The renal urodilatin system: clinical implications

Wolf-Georg Forssmann*, Markus Meyer and Kristin Forssmann1

IPF PharmaCeuticals GmbH, An-Institute of Hannover Medical School, Feodor Lynen-Strasse 31, D–30 625 Hannover, Germany

* Corresponding author wgforssmann{at}gmx.de

A renal natriuretic peptide and the ‘renal urodilatin system’ were identified after the observation that immunoassayable ANP in urine may not be identical to the circulating cardiac hormone ANP, which is a peptide of 28 amino acids. Urodilatin (INN: Ularitide) is a natriuretic peptide isolated from human urine and belongs to the family of A-type natriuretic peptides. Urodilatin is differentially processed to a peptide of 32 amino acids from the same precursor as ANP. It is synthesized in kidney tubular cells and secreted luminally. After secretion from epithelial cells of the distal and/or connecting tubules, Urodilatin interacts downstream at distal segments of the nephron with luminally located receptors whereby it regulates Na+ and water reabsorption. Thus, the physiological function of the renal Urodilatin system can be described as a paracrine intrarenal regulator for Na+ and water homeostasis, considering Urodilatin as a real diuretic-natriuretic regulatory peptide. However, the regulation upon which the Urodilatin secretion depends is still not clear. Since Urodilatin has been discovered, a great number of pharmacological and clinical investigations have been carried out using Urodilatin as a drug for several indications. So far, clinical phase I and II studies for acute renal failure, congestive heart failure, and bronchial asthma have been performed.

KEYWORDS Antihypertensive/diuretic agents; Blood pressure; Heart failure; Hormones; Natriuretic peptide; Renal function; Vasoconstrition/dilation

1 Working at CardioPep Pharma GmbH.


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