© 2001 by European Society of Cardiology
Copyright © 2001, European Society of Cardiology
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
Centre for Cardiovascular Biology and Medicine, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
* Corresponding author. Tel.: +44-20-7679-6620; fax: +44-20-7679-6212 i.zachary{at}ucl.ac.uk
The central role of vascular endothelial growth factor (VEGF) in angiogenesis in health and disease makes it attractive both as a therapeutic target for anti-angiogenic drugs and as a pro-angiogenic cytokine for the treatment of ischaemic heart disease. While VEGF binds to two receptor protein tyrosine kinases, VEGFR1 (Flt-1) and VEGFR2 (KDR), most biological functions of VEGF are mediated via VEGFR2, and the role of VEGFR1 is currently unknown. Neuropilin-1, a non-tyrosine kinase transmembrane molecule, may function as a co-receptor for VEGFR2. Considerable progress has recently been made towards delineating the signal transduction pathways distal to activation of VEGFR2. Activation of the mitogen-activated protein kinase, protein kinase C and Akt pathways are all strongly implicated in mediating diverse cellular biological functions of VEGF, including cell survival, proliferation, the generation of nitric oxide and prostacyclin and angiogenesis. Upregulation of metalloproteinases, activation of focal adhesion kinase and interactions between VEGF receptors and integrins are strongly implicated in VEGF-induced endothelial cell migration. Recent findings suggest important roles for the vasodilators nitric oxide and prostacyclin, in linking post-receptor signaling networks to downstream biological effects and in mediating some in vivo endothelial functions of VEGF.
KEYWORDS bFGF, basic fibroblast growth factor (FGF-2); eNOS, endothelial constitutive nitric oxide synthase; ERK, extracellular signal-regulated kinase; FAK, focal adhesion kinase; HUVEC, human umbilical vein endothelial cell; PGI2, prostacyclin; PKC, protein kinase C; VEGF, vascular endothelial growth factor A; VSMC, vascular smooth muscle cell; vWF, von Willebrand factor
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||||
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||||
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||||
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||||
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||||
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||||
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L. D. D'Andrea, G. Iaccarino, R. Fattorusso, D. Sorriento, C. Carannante, D. Capasso, B. Trimarco, and C. Pedone Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide PNAS, October 4, 2005; 102(40): 14215 - 14220. [Abstract] [Full Text] [PDF] |
||||
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E. Toyota, D. C. Warltier, T. Brock, E. Ritman, C. Kolz, P. O'Malley, P. Rocic, M. Focardi, and W. M. Chilian Vascular Endothelial Growth Factor Is Required for Coronary Collateral Growth in the Rat Circulation, October 4, 2005; 112(14): 2108 - 2113. [Abstract] [Full Text] [PDF] |
||||
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E. Elsheikh, M. Uzunel, Z. He, J. Holgersson, G. Nowak, and S. Sumitran-Holgersson Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity Blood, October 1, 2005; 106(7): 2347 - 2355. [Abstract] [Full Text] [PDF] |
||||
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F. Roviezzo, S. Tsigkos, A. Kotanidou, M. Bucci, V. Brancaleone, G. Cirino, and A. Papapetropoulos Angiopoietin-2 Causes Inflammation in Vivo by Promoting Vascular Leakage J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 738 - 744. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Mac Gabhann and A. S. Popel Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1: a computational model Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2851 - H2860. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. J. Knot, I. Laher, E. A. Sobie, S. Guatimosim, L. Gomez-Viquez, H. Hartmann, L.-S. Song, W.J. Lederer, W. F. Graier, R. Malli, et al. Twenty Years of Calcium Imaging: Cell Physiology to Dye For Mol. Interv., April 1, 2005; 5(2): 112 - 127. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. H Wu, S. Y Yuan, and H. J Granger The protein kinase MEK1/2 mediate vascular endothelial growth factor- and histamine-induced hyperpermeability in porcine coronary venules J. Physiol., February 15, 2005; 563(1): 95 - 104. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Tammela, B. Enholm, K. Alitalo, and K. Paavonen The biology of vascular endothelial growth factors Cardiovasc Res, February 15, 2005; 65(3): 550 - 563. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. H. Annex and M. Simons Growth factor-induced therapeutic angiogenesis in the heart: protein therapy Cardiovasc Res, February 15, 2005; 65(3): 649 - 655. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. M. Short, A. Derrien, R. P. Narsimhan, J. Lawler, D. E. Ingber, and B. R. Zetter Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by {beta}1 integrins J. Cell Biol., February 14, 2005; 168(4): 643 - 653. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. J. Hicklin and L. M. Ellis Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis J. Clin. Oncol., February 10, 2005; 23(5): 1011 - 1027. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Reinhardt, P. Schaarschmidt, A. Bossert, A. Luske, G. Finkenzeller, T. Mertens, and D. Michel Upregulation of functionally active vascular endothelial growth factor by human cytomegalovirus J. Gen. Virol., January 1, 2005; 86(1): 23 - 30. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Abadie, F. Bregeon, L. Papazian, F. Lange, B. Chailley-Heu, P. Thomas, P. Duvaldestin, S. Adnot, B. Maitre, and C. Delclaux Decreased VEGF concentration in lung tissue and vascular injury during ARDS Eur. Respir. J., January 1, 2005; 25(1): 139 - 146. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Yamauchi, Y. Nishimura, S. Shigematsu, Y. Takeuchi, J. Nakamura, T. Aizawa, and K. Hashizume Vascular Endothelial Cell Growth Factor Attenuates Actions of Transforming Growth Factor-{beta} in Human Endothelial Cells J. Biol. Chem., December 31, 2004; 279(53): 55104 - 55108. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. L. Yauch, E. E. Kadel III, C. Nicholas, S. Tetangco, and D. O. Clary Transcriptional-Based Screens for Pathway-Specific, High-Throughput Target Discovery in Endothelial Cells J Biomol Screen, December 1, 2004; 9(8): 704 - 711. [Abstract] [PDF] |
||||
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C.N. Mowa, S. Jesmin, I. Sakuma, S. Usip, H. Togashi, M. Yoshioka, Y. Hattori, and R. Papka Characterization of Vascular Endothelial Growth Factor (VEGF) in the Uterine Cervix over Pregnancy: Effects of Denervation and Implications for Cervical Ripening J. Histochem. Cytochem., December 1, 2004; 52(12): 1665 - 1674. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Zhao, K. Egashira, K.-i. Hiasa, M. Ishibashi, S. Inoue, K. Ohtani, C. Tan, M. Shibuya, A. Takeshita, and K. Sunagawa Essential Role of Vascular Endothelial Growth Factor and Flt-1 Signals in Neointimal Formation After Periadventitial Injury Arterioscler Thromb Vasc Biol, December 1, 2004; 24(12): 2284 - 2289. [Abstract] [Full Text] [PDF] |
||||
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||||
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C. Sarkar, D. Chakroborty, R. B. Mitra, S. Banerjee, P. S. Dasgupta, and S. Basu Dopamine in vivo inhibits VEGF-induced phosphorylation of VEGFR-2, MAPK, and focal adhesion kinase in endothelial cells Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1554 - H1560. [Abstract] [Full Text] [PDF] |
||||
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F. Le Boeuf, F. Houle, and J. Huot Regulation of Vascular Endothelial Growth Factor Receptor 2-mediated Phosphorylation of Focal Adhesion Kinase by Heat Shock Protein 90 and Src Kinase Activities J. Biol. Chem., September 10, 2004; 279(37): 39175 - 39185. [Abstract] [Full Text] [PDF] |
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E. J. Armstrong and J. Bischoff Heart Valve Development: Endothelial Cell Signaling and Differentiation Circ. Res., September 3, 2004; 95(5): 459 - 470. [Abstract] [Full Text] [PDF] |
||||
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L. Cheng, H. Jia, M. Lohr, A. Bagherzadeh, D. I. R. Holmes, D. Selwood, and I. Zachary Anti-chemorepulsive Effects of Vascular Endothelial Growth Factor and Placental Growth Factor-2 in Dorsal Root Ganglion Neurons Are Mediated via Neuropilin-1 and Cyclooxygenase-derived Prostanoid Production J. Biol. Chem., July 16, 2004; 279(29): 30654 - 30661. [Abstract] [Full Text] [PDF] |
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R. A. Nordal, A. Nagy, M. Pintilie, and C. S. Wong Hypoxia and Hypoxia-Inducible Factor-1 Target Genes in Central Nervous System Radiation Injury: A Role for Vascular Endothelial Growth Factor Clin. Cancer Res., May 15, 2004; 10(10): 3342 - 3353. [Abstract] [Full Text] [PDF] |
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Y. Wu, Q. Zhang, D. K. Ann, A. Akhondzadeh, H. S. Duong, D. V. Messadi, and A. D. Le Increased vascular endothelial growth factor may account for elevated level of plasminogen activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts Am J Physiol Cell Physiol, April 1, 2004; 286(4): C905 - C912. [Abstract] [Full Text] [PDF] |
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J.-K. Min, K.-Y. Han, E.-C. Kim, Y.-M. Kim, S.-W. Lee, O.-H. Kim, K.-W. Kim, Y. S. Gho, and Y.-G. Kwon Capsaicin Inhibits in Vitro and in Vivo Angiogenesis Cancer Res., January 15, 2004; 64(2): 644 - 651. [Abstract] [Full Text] [PDF] |
||||
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S Battersby, H O D Critchley, A J de Brum-Fernandes, and H N Jabbour Temporal expression and signalling of prostacyclin receptor in the human endometrium across the menstrual cycle Reproduction, January 1, 2004; 127(1): 79 - 86. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Mac Gabhann and A. S. Popel Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H153 - H164. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. H Wu, M. Guo, S. Y Yuan, and H. J Granger Focal adhesion kinase mediates porcine venular hyperpermeability elicited by vascular endothelial growth factor J. Physiol., November 1, 2003; 552(3): 691 - 699. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. E. Olah and C. C. Caldwell Adenosine Receptors and Mammalian Toll-Like Receptors: Synergism in Macrophages Mol. Interv., October 1, 2003; 3(7): 370 - 374. [Abstract] [Full Text] |
||||
![]() |
R. Salcedo, X. Zhang, H. A. Young, N. Michael, K. Wasserman, W.-H. Ma, M. Martins-Green, W. J. Murphy, and J. J. Oppenheim Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells Blood, September 15, 2003; 102(6): 1966 - 1977. [Abstract] [Full Text] [PDF] |
||||
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R. Benndorf, R. H. Boger, S. Ergun, A. Steenpass, and T. Wieland Angiotensin II Type 2 Receptor Inhibits Vascular Endothelial Growth Factor-Induced Migration and In Vitro Tube Formation of Human Endothelial Cells Circ. Res., September 5, 2003; 93(5): 438 - 447. [Abstract] [Full Text] [PDF] |
||||
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Y.-B. Shui, X. Wang, J. S. Hu, S.-P. Wang, C. M. Garcia, J. D. Potts, Y. Sharma, and D. C. Beebe Vascular Endothelial Growth Factor Expression and Signaling in the Lens Invest. Ophthalmol. Vis. Sci., September 1, 2003; 44(9): 3911 - 3919. [Abstract] [Full Text] [PDF] |
||||
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F. J. Giles, A. T. Stopeck, L. R. Silverman, J. E. Lancet, M. A. Cooper, A. L. Hannah, J. M. Cherrington, A.-M. O'Farrell, H. A. Yuen, S. G. Louie, et al. SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes Blood, August 1, 2003; 102(3): 795 - 801. [Abstract] [Full Text] [PDF] |
||||
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B. Larrivee, D. R. Lane, I. Pollet, P. L. Olive, R. K. Humphries, and A. Karsan Vascular Endothelial Growth Factor Receptor-2 Induces Survival of Hematopoietic Progenitor Cells J. Biol. Chem., June 6, 2003; 278(24): 22006 - 22013. [Abstract] [Full Text] [PDF] |
||||
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N. D. Lawson, J. W. Mugford, B. A. Diamond, and B. M. Weinstein phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development Genes & Dev., June 1, 2003; 17(11): 1346 - 1351. [Abstract] [Full Text] [PDF] |
||||
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S. Nakao, T. Kuwano, T. Ishibashi, M. Kuwano, and M. Ono Synergistic Effect of TNF-{alpha} in Soluble VCAM-1-Induced Angiogenesis Through {alpha}4 Integrins J. Immunol., June 1, 2003; 170(11): 5704 - 5711. [Abstract] [Full Text] [PDF] |
||||
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V. Louzier, B. Raffestin, A. Leroux, D. Branellec, J. M. Caillaud, M. Levame, S. Eddahibi, and S. Adnot Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L926 - L937. [Abstract] [Full Text] [PDF] |
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K. D. Miller, C. J. Sweeney, and G. W. Sledge The Snark is a Boojum: the continuing problem of drug resistance in the antiangiogenic era Ann. Onc., January 1, 2003; 14(1): 20 - 28. [Abstract] [Full Text] [PDF] |
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H. Y. Shin, M. L. Smith, K. J. Toy, P. M. Williams, R. Bizios, and M. E. Gerritsen VEGF-C mediates cyclic pressure-induced endothelial cell proliferation Physiol Genomics, December 3, 2002; 11(3): 245 - 251. [Abstract] [Full Text] [PDF] |
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T. M. Hazzard, F. Xu, and R. L. Stouffer Injection of Soluble Vascular Endothelial Growth Factor Receptor 1 into the Preovulatory Follicle Disrupts Ovulation and Subsequent Luteal Function in Rhesus Monkeys Biol Reprod, October 1, 2002; 67(4): 1305 - 1312. [Abstract] [Full Text] [PDF] |
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J. C Wanstall, A. Gambino, T. K Jeffery, M. M Cahill, D. Bellomo, N. K Hayward, and G. F Kay Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension Cardiovasc Res, August 1, 2002; 55(2): 361 - 368. [Abstract] [Full Text] [PDF] |
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B. Li, A. K. Ogasawara, R. Yang, W. Wei, G.-W. He, T. F. Zioncheck, S. Bunting, A. M. de Vos, and H. Jin KDR (VEGF Receptor 2) Is the Major Mediator for the Hypotensive Effect of VEGF Hypertension, June 1, 2002; 39(6): 1095 - 1100. [Abstract] [Full Text] [PDF] |
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L. Bogin and H. Degani Hormonal Regulation of VEGF in Orthotopic MCF7 Human Breast Cancer Cancer Res., April 1, 2002; 62(7): 1948 - 1951. [Abstract] [Full Text] [PDF] |
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L. Vincent, C. Soria, F. Mirshahi, P. Opolon, Z. Mishal, J.-P. Vannier, J. Soria, and L. Hong Cerivastatin, an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, Inhibits Endothelial Cell Proliferation Induced by Angiogenic Factors In Vitro and Angiogenesis in In Vivo Models Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 623 - 629. [Abstract] [Full Text] [PDF] |
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R. Yang, A. K. Ogasawara, T. F. Zioncheck, Z. Ren, G.-W. He, G. G. DeGuzman, N. Pelletier, B.-Q. Shen, S. Bunting, and H. Jin Exaggerated Hypotensive Effect of Vascular Endothelial Growth Factor in Spontaneously Hypertensive Rats Hypertension, March 1, 2002; 39(3): 815 - 820. [Abstract] [Full Text] [PDF] |
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D. Thuringer, L. Maulon, and C. Frelin Rapid Transactivation of the Vascular Endothelial Growth Factor Receptor KDR/Flk-1 by the Bradykinin B2 Receptor Contributes to Endothelial Nitric-oxide Synthase Activation in Cardiac Capillary Endothelial Cells J. Biol. Chem., January 11, 2002; 277(3): 2028 - 2032. [Abstract] [Full Text] [PDF] |
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L. Vincent, C. Soria, F. Mirshahi, P. Opolon, Z. Mishal, J.-P. Vannier, J. Soria, and L. Hong Cerivastatin, an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, Inhibits Endothelial Cell Proliferation Induced by Angiogenic Factors In Vitro and Angiogenesis in In Vivo Models Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 623 - 629. [Abstract] [Full Text] [PDF] |
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