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Cardiovascular Research 2001 49(3):497-506; doi:10.1016/S0008-6363(00)00285-6
© 2001 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

Experimental evaluation of coronary collateral development

Ellis F Unger*

Division of Clinical Trial Design and Analysis, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD 20852-1428, USA

* Tel.: +1-301-827-5350; fax: +1-301-827-5394 ungere{at}cber.fda.gov

During the last decade, there has been great interest in the potential use of biologic agents and mechanical techniques to enhance myocardial collateral development. Available experimental methods to detect the effects of interventions designed to improve collateral function include assessment of vascular cell proliferation, quantification of vessel number and size, appraisal of myocardial perfusion, and evaluation of myocardial function. The purpose of this review is to discuss the various experimental approaches for the evaluation of coronary collateral development, highlighting the relative strengths and limitations of the commonly used animal models and methods of assessment.

KEYWORDS Blood flow; Collateral circulation; Coronary circulation; Microcirculation; Regional blood flow

* The opinions expressed are those of the author, and not necessarily those of the U.S. Food and Drug Administration.


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