© 2001 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
The effects of gemfibrozil upon the metabolism of chylomicron-like emulsions in patients with endogenous hypertriglyceridemia
aThe Heart Institute of the Medical School Hospital (InCor), University of São Paulo, São Paulo, Brazil
bFaculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
* Corresponding author. Laboratório de Metabolismo Lipídico, Instituto do Coração-HCFMUSP, Av. Dr. Enéas C. Aguiar, 44, 05403-000 Sao Paulo-SP, Brazil. Tel.: +55-11-3068-8794; fax: +55-11-3063-0779 ramarans{at}usp.br
Objective: To evaluate the effects of gemfibrozil upon the intravascular metabolism of chylomicron-like emulsions in endogenous hypertriglyceridemia. Methods: We evaluated the plasma kinetics of a chylomicron-like emulsion in 39 subjects: 27 hypertriglyceridemics, total cholesterol (TC) expressed as median (%25; %75) 7.47 (6.1; 8.19) mmol/l and plasma triglycerides (TG) 4.28 (3.6; 18.5) mmol/l and in 12 normolipidemics, TC 4.7 (3.85; 5.37) mmol/l and TG 0.91 (0.64; 1.75) mmol/l. Hypertriglyceridemics were evaluated at baseline and after a 30-day 1200-mg/day gemfibrozil (n = 8) or placebo treatment (n = 7). The emulsion labelled with 14C-cholesteryl oleate (14C-CO) and 3H-triolein (3H-TO) was injected intravenously after a 12-h fast. The plasma kinetics of 3H-TO and 14C-CO were determined to assess, respectively, lipolysis and clearance of chylomicron and remnants by compartmental analysis. Results: The residence times (in minutes) of 3H-TO and 14C-CO of hypertriglyceridemics were roughly twice the values of normolipidemics, i.e. 8.0 (5.5; 12.0) versus 15.0 (11.0; 24.0) and 21.5 (14.0; 33.0) versus 44.0 (32.0; 72.0), P = 0.001. Gemfibrozil treatment of hypertriglyceridemic patients reduced the residence times of 3H-TO and 14C-CO, respectively, by 46% (P = 0.003) and 53% (P = 0.008). Effects were noted on the slow phase of emulsion plasma removal, which was reduced in hypertriglyceridemics. After treatment, the emulsion residence times determined in hypertriglyceridemics attained the values of the normolipidemic group. Conclusions: Gemfibrozil treatment normalised the defects in chylomicron-like emulsion catabolism observed in endogenous hypertriglyceridemia patients.
KEYWORDS Atherosclerosis; Cholesterol; Computer modelling; Lipid metabolism; Lipoproteins
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. C. Sposito, P. A. Lemos, R. D. Santos, W. Hueb, C. G. C. Vinagre, E. Quintella, O. Carneiro, M. J. Chapman, J. A. F. Ramires, and R. C. Maranhao Impaired intravascular triglyceride lipolysis constitutes a marker of clinical outcome in patients with stable angina undergoing secondary prevention treatment: A long-term follow-up study J. Am. Coll. Cardiol., June 16, 2004; 43(12): 2225 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Santos, W. Hueb, A. A. Oliveira, J. A. F. Ramires, and R. C. Maranhao Plasma kinetics of a cholesterol-rich emulsion in subjects with or without coronary artery disease J. Lipid Res., March 1, 2003; 44(3): 464 - 469. [Abstract] [Full Text] [PDF]
|
|