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Cardiovascular Research 2000 48(3):455-463; doi:10.1016/S0008-6363(00)00203-0
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

A new approach to determine parallel conductance for left ventricular volume measurements

L Korneta,*, J.J Schreuderb, E.T van der Veldec, J Baanc and J.R.C Jansend

aDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
bDepartment of Cardiac Surgery, San Raffaele Hospital, Milan, Italy
cDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
dDepartment of Intensive Care, Leiden University Medical Center, Leiden, The Netherlands

* Corresponding author. Tel.: +31-43-388-1209; fax: +31-43-388-4166 l.kornet{at}fys.unimaas.nl

Objectives: To determine absolute ventricular volume with the conductance catheter technique, the electrical conductance of tissues and fluids (parallel conductance) around the ventricle should be determined precisely. Methods: A new objective method to estimate parallel conductance based on analysis of the dilution curve of hypertonic saline was investigated. The parallel conductances obtained with the new method (Gap) were compared to those obtained with the conventional method (Glp). The study was performed in the left ventricle of 12 patients. Results: Gap was not significantly different from Glp. For the Glp method the average percentage difference between duplicate values, both taken as absolute values, was 15.06% and for the Gap method it was 4.01%. Thus the reproducibility of the method is a factor four better than that of the method. This difference appeared to be significant. Conclusion: We conclude that a smaller number of injections will be required to obtain the same precision using our method.

KEYWORDS Cardiomyopathy; Cardiovascular surgery; Conduction (block); Contractile function; Heart failure


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