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Cardiovascular Research 2000 48(1):13-22; doi:10.1016/S0008-6363(00)00172-3
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Calcium signalling in endothelial cells

Quang-Kim Trana, Kyoichi Ohashib and Hiroshi Watanabeb,*

aDepartment of Internal Medicine III, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu 431-3192, Japan
bDepartment of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu 431-3192, Japan

* Corresponding author. Tel./fax: +81-53-435-2384 hwat{at}hama-med.ac.jp

Vascular endothelial cells are ubiquitous for their presence in each and every vessel and unique for their multifunctional nature. A large number of endothelial functions depend to various extents on changes in intracellular Ca2+ concentration. Reviewed are endothelial Ca2+ stores, Ca2+ channels, and in-out-in Ca2+ signalling events, from ligand-binding on the plasma membrane into depletion of intracellular Ca2+ stores and therefrom out to transplasmalemmal Ca2+ entry that is of prime importance for many endothelial functions. Special emphasis is placed on mechanisms regulating store-operated Ca2+ entry including a Ca2+ influx factor, the vesicle secretion-like model, the conformational coupling model, the membrane potential, cytochrome P450, protein tyrosine kinase, myosin light chain kinase and nitric oxide.

KEYWORDS Endothelial factors; Calcium (cellular); Ca-channel; Signal transduction; Protein kinases


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