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Cardiovascular Research 2000 47(4):806-812; doi:10.1016/S0008-6363(00)00131-0
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Lipoprotein lipase gene polymorphism, cholesterol subfractions and myocardial infarction in large samples of the general population

Stephan R Holmera,*, Christian Hengstenberga, Björn Mayera, Angela Döringb, Hannelore Löwelb, Susanne Engelb, Hans-Werner Hensec, Melanie Wolfa, Gernot Kleind, Günter A.J Rieggera and Heribert Schunkerta

aKlinik und Poliklinik für Innere Medizin II, University of Regensburg, Franz-Josef-Strauss-Allee 11, D 93042 Regensburg, Germany
bGSF Forschungszentrum-Institut für Epidemiologie und Sozialmedizin, München-Neuherberg, Germany
cInstitut für Epidemiologie und Sozialmedizin-Klinische Epidemiologie, University of Münster, Münster, Germany
dKlinik Höhenried für Herz- und Kreislaufkrankheiten, Bernried, Germany

* Corresponding author. Tel.: +49-941-944-7208; fax: +49-941-944-7213 stephan.holmer{at}klinik.uni-regensburg.de

Objective: Genetic variants of the lipoprotein lipase gene have been associated with dyslipidemia and coronary artery disease. However, data have been inconsistent and are mainly based on selected predominantly male patient groups. Methods: We evaluated the influence of the HindIII restriction fragment length polymorphism on lipid levels in the general population (1361 participants of a large population-based survey from Augsburg, Germany; 50% women) as well as the association of this polymorphism with the risk of myocardial infarction (MI; genotype frequencies in 1159 patients with documented MI under 60 years of age). Results: In the population-based survey, a highly significant association between the frequent H2H2 genotype and unfavorable cholesterol subfraction levels was observed in men and in postmenopausal women whereas no significant association was observed in premenopausal women (uni- and multivariate analysis). Such unfavorable lipid levels in homozygotes for the H2 allele may be expected to be associated with a 19–25% increased risk to suffer from myocardial infarction (MI). Nevertheless, genotype and allele frequencies in the general population were not different from those in patients with previous MI (H2H2 genotype frequency 51.3% vs. 53.2%, respectively; P=0.63). Conclusion: This large study shows that the H2H2 genotype of the lipoprotein lipase gene polymorphism is associated with unfavorable lipid levels. Estrogen status may modulate this association in women. The effects of the genotype on lipid levels were apparently not strong enough to reveal a significant association with MI.

KEYWORDS Lipoproteins; Infarction; Gene expression; Lipid metabolism; Cholesterol


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