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Cardiovascular Research 2000 47(4):788-796; doi:10.1016/S0008-6363(00)00139-5
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Atrial high energy phosphate content and mitochondrial enzyme activity during chronic atrial fibrillation

Jannie Ausmaa,b,*, Will A Coumansa, Hans Duimelb, Ger J Van der Vussea, Maurits A Allessiea and Marcel Borgersb

aDepartment of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
bDepartment of Molecular Cell Biology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands

* Corresponding author. Tel.: +31-43-388-1076; fax: +31-43-388-4166 jannie.ausma{at}fys.unimaas.nl

Objective: Prolonged atrial fibrillation (AF) results in (ultra)structural remodelling of atrial cardiomyocytes resembling alterations seen in ischemia-induced ventricular hibernation. The mechanisms underlying these changes are incompletely understood. In the present study we explored the hypothesis that a profound imbalance in energy status during chronic AF acts as a stimulus for structural remodelling. Methods and Results: The content of high energy-phosphates and related compounds together with a selected number of mitochondrial enzymes, known to be altered under ischemic conditions, were determined in tissue samples taken from atria of goats in sinus rhythm (SR) and after 1, 2, 4, 8 and 16 weeks of AF maintained by burst pacing. Atrial remodelling was quantified by counting the percentage of cells with >10% myolysis. During AF structural remodelling developed progressively, after 8 weeks about 40% of the atrial myocytes were affected. The concentration of adenine nucleotides and their degradation products did not change significantly during AF. Also the activity of mitochondrial cytochrome c oxidase activity was similar during AF and SR. Mitochondrial NADH-oxidase and proton-translocating ATPase activities were not induced by AF. The tissue content of phosphocreatine decreased during the first week by 60%, but completely recovered between 8 and 16 weeks of AF. Conclusions: The analysis of adenine nucleotides during AF provided no indication for the development of severe atrial ischemia. This notion is supported by enzyme cytochemical findings. However, AF-induced atrial remodelling was associated with a transient lowering of phosphocreatine content, suggesting an increase in energy demand during the early phase of AF. The subsequent recovery of the phosphocreatine pool indicates restoration of the balance between energy demand and supply in chronically fibrillating atria.

KEYWORDS Atrial function; Energy metabolism; Hibernation; Mitochondria; Remodeling; Supraventr. arrhythmia

{star} This study was presented in part at the 72nd Annual Scientific Session of the American Heart Association (Circulation 1999;100:I-11).


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