© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes
aInstitute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, Taipei, Taiwan
bDepartment of Physiology, College of Medicine, Chang Gung University, Taoyuan, Taiwan
cCenter of General Studies, Chang Gung University, Taoyuan, Taiwan
* Corresponding author. Tel.: +886-2-2356-2221; fax: +886-2-2391-5602 mjsu{at}ha.mc.ntu.edu.tw
Background: The major objective of the present study was to examine the cardioprotective effect of resveratrol, an antioxidant presents in red wines, in the rat after ischemia and ischemia–reperfusion (I–R). Methods: The left main coronary artery was occluded for 30 or 5 min followed by a 30-min reperfusion in anesthetized rats. Animals were preinfused with and without resveratrol before occlusion and the severity of ischemia- and I–R-induced arrhythmias and mortality were compared. Results: Resveratrol pretreatment had no effect on ischemia-induced arrhythmias nor on mortality. In contrast, a dramatic protective effects were observed against I–R-induced arrhythmias and mortality. Resveratrol pretreatment both reduced the incidence and duration of ventricular tachycardia (VT) and ventricular fibrillation (VF). During the same period, resveratrol pretreatment also increased nitric oxide (NO) and decreased lactate dehydrogenase levels in the carotid blood. Conclusions: Resveratrol is a potent antiarrhythmic agent with cardioprotective properties in I–R rats. The cardioprotective effects of resveratrol in the I–R rats may be correlated with its antioxidant activity and upregulation of NO production.
KEYWORDS Arrhythmia, mechanisms; Free radicals; Ischemia; Nitric oxide; Reperfusion
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