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Cardiovascular Research 2000 47(1):38-48; doi:10.1016/S0008-6363(00)00087-0
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Vascular function in preeclampsia

Marja J VanWijka,b,*, Karolina Kublickienec, Kees Boera and Ed VanBavelb

aDepartment of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands
bDepartment of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands
cDepartment of Obstetrics and Gynaecology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden

* Corresponding author. Tel.: +31-20-566-9111; fax: +31-20-696-3489 m.j.vanwijk{at}amc.uva.nl

Preeclampsia is a multisystem disorder peculiar to human pregnancy. It occurs in 4–5% of all pregnancies and remains a leading cause of maternal and neonatal mortality and morbidity. The pathophysiology of this syndrome is not fully understood. Two stages of vascular dysfunction seem to be involved. In the early stage suboptimal development of the placenta and a hemodynamic maladaptation to pregnancy exist. At this stage maternal constitutional factors such as genetic and immunological factors and pre-existing vascular diseases may play a role. Due to this defective placentation a factor is released from the placenta, supposedly under the influence of ischemia. This factor then results in the late vascular dysfunction characterised mainly by a generalised endothelial dysfunction, leading to the clinical syndrome of preeclampsia. This review attempts to unravel the mechanisms that may contribute to preeclampsia-associated changes in vascular function and to indicate the research needed to improve our understanding of this disease.

KEYWORDS Hypertension; Hemodynamics; Endothelial function; Arteries; Vasoconstriction/dilation


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