© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
Infarct scar: a dynamic tissue
Division of Cardiovascular Diseases, Department of Internal Medicine, University of Tennessee, Memphis College of Medicine, Rm. 353 Dobbs Research Institute, 951 Court Avenue, Memphis, TN 38163, USA
* Corresponding author. Tel.: +1-901-448-5759; fax: +1-901-448-8084 ktweber{at}utmem.edu
Infarct scar, a requisite to the rebuilding of necrotic myocardium following myocardial infarction (MI), has long been considered inert. Earlier morphologic studies suggested healing at the infarct site was complete within 6–8 weeks following MI and resultant scar tissue, albeit necessary, was acellular and simply fibrillar collagen. Utilizing molecular and cellular biologic technologies, recent studies indicate otherwise. Infarct scar is composed of phenotypically transformed fibroblast-like cells, termed myofibroblasts (myoFb) because they express alpha-smooth muscle actin (
-SMA) and these microfilaments confer contractile behavior in response to various peptides and amines. These cells are nourished by a neovasculature and are persistent at the MI site, where they are metabolically active expressing components requisite to angiotensin (Ang) peptide generation, including converting enzyme, receptors for AngII and transforming growth factor (TGF)-β1. They continue to elaborate fibrillar type I collagen. Their generation of these peptides contribute to ongoing scar tissue collagen turnover and to fibrous tissue formation of noninfarcted myocardium. Infarct scar contraction accounts for its thinning and its tonus may contribute to abnormal ventricular chamber stiffness with diastolic dysfunction. Infarct scar is a dynamic tissue: cellular, vascularized, metabolically active and contractile. Pharmacologic interventions with angiotensin converting enzyme inhibitor or AT1 receptor antagonist has proven effective in attenuating scar tissue metabolic activity and minimizing adverse accumulation of fibrous tissue in noninfarcted myocardium.
KEYWORDS Angiotensin; Fibrosis; Growth factors; Infarction
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|
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|
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|
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|
|
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|
|
|
|
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|
 M. Shimazaki, K. Nakamura, I. Kii, T. Kashima, N. Amizuka, M. Li, M. Saito, K. Fukuda, T. Nishiyama, S. Kitajima, et al. Periostin is essential for cardiac healingafter acute myocardial infarction J. Exp. Med., February 18, 2008; 205(2): 295 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. El-Helou, C. Proulx, H. Gosselin, R. Clement, A. Mimee, L. Villeneuve, and A. Calderone Dexamethasone treatment of post-MI rats attenuates sympathetic innervation of the infarct region J Appl Physiol, January 1, 2008; 104(1): 150 - 156. [Abstract] [Full Text] [PDF]
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
|
 |
|
 C. Jackowski, A. Christe, M. Sonnenschein, E. Aghayev, and M. J. Thali Postmortem unenhanced magnetic resonance imaging of myocardial infarction in correlation to histological infarction age characterization Eur. Heart J., October 2, 2006; 27(20): 2459 - 2467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Christman and R. J. Lee Biomaterials for the Treatment of Myocardial Infarction J. Am. Coll. Cardiol., September 5, 2006; 48(5): 907 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
C. K. Sen, S. Khanna, and S. Roy Perceived hyperoxia: Oxygen-induced remodeling of the reoxygenated heart Cardiovasc Res, July 15, 2006; 71(2): 280 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 V. El-Helou, J. Dupuis, C. Proulx, J. Drapeau, R. Clement, H. Gosselin, L. Villeneuve, L. Manganas, and A. Calderone Resident Nestin+ Neural-Like Cells and Fibers Are Detected in Normal and Damaged Rat Myocardium Hypertension, November 1, 2005; 46(5): 1219 - 1225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Brown Cardiac extracellular matrix: a dynamic entity Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H973 - H974. [Full Text] [PDF]
|
|
|
|
|
|
A. S. Blom, R. Mukherjee, J. J. Pilla, A. S. Lowry, W. M. Yarbrough, J. T. Mingoia, J. W. Hendrick, R. E. Stroud, J. E. McLean, J. Affuso, et al. Cardiac Support Device Modifies Left Ventricular Geometry and Myocardial Structure After Myocardial Infarction Circulation, August 30, 2005; 112(9): 1274 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Dai, L. E. Wold, J. S. Dow, and R. A. Kloner Thickening of the Infarcted Wall by Collagen Injection Improves Left Ventricular Function in Rats: A Novel Approach to Preserve Cardiac Function After Myocardial Infarction J. Am. Coll. Cardiol., August 16, 2005; 46(4): 714 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wang, R. Ansari, Y. Sun, A. E. Postlethwaite, K. T. Weber, and M. F. Kiani The scar neovasculature after myocardial infarction in rats Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H108 - H113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Freed, R. H. Cunnington, A. L. Dangerfield, J. S. Sutton, and I. M.C. Dixon Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart Cardiovasc Res, March 1, 2005; 65(4): 782 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sugano, T. Anzai, T. Yoshikawa, Y. Maekawa, T. Kohno, K. Mahara, K. Naito, and S. Ogawa Granulocyte colony-stimulating factor attenuates early ventricular expansion after experimental myocardial infarction Cardiovasc Res, February 1, 2005; 65(2): 446 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Camelliti, T. K. Borg, and P. Kohl Structural and functional characterisation of cardiac fibroblasts Cardiovasc Res, January 1, 2005; 65(1): 40 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Orlandi, A. Francesconi, M. Marcellini, A. Ferlosio, and L. G. Spagnoli Role of ageing and coronary atherosclerosis in the development of cardiac fibrosis in the rabbit Cardiovasc Res, December 1, 2004; 64(3): 544 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Maekawa, T. Anzai, T. Yoshikawa, Y. Sugano, K. Mahara, T. Kohno, T. Takahashi, and S. Ogawa Effect of granulocyte-macrophage colony-stimulating factor inducer on left ventricular remodeling after acute myocardial infarction J. Am. Coll. Cardiol., October 6, 2004; 44(7): 1510 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sandhu, K. Teichert-Kuliszewska, S. Nag, G. Proteau, M. J. Robb, A. I.M. Campbell, M. A. Kuliszewski, M. J.B. Kutryk, and D. J. Stewart Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat Cardiovasc Res, October 1, 2004; 64(1): 115 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Moriwaki, A. Stempien-Otero, M. Kremen, A. E. Cozen, and D. A. Dichek Overexpression of Urokinase by Macrophages or Deficiency of Plasminogen Activator Inhibitor Type 1 Causes Cardiac Fibrosis in Mice Circ. Res., September 17, 2004; 95(6): 637 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dimmeler and A. M. Zeiher Wanted! The best cell for cardiac regeneration J. Am. Coll. Cardiol., July 21, 2004; 44(2): 464 - 466. [Full Text] [PDF]
|
|
|
|
|
|
H. Abdel-Aty, A. Zagrosek, J. Schulz-Menger, A. J. Taylor, D. Messroghli, A. Kumar, M. Gross, R. Dietz, and M. G. Friedrich Delayed Enhancement and T2-Weighted Cardiovascular Magnetic Resonance Imaging Differentiate Acute From Chronic Myocardial Infarction Circulation, May 25, 2004; 109(20): 2411 - 2416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Camelliti, G. P Devlin, K. G Matthews, P. Kohl, and C. R Green Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction Cardiovasc Res, May 1, 2004; 62(2): 415 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Yang, X.-P. Yang, Y.-H. Liu, J. Xu, O. Cingolani, N.-E. Rhaleb, and O. A. Carretero Ac-SDKP Reverses Inflammation and Fibrosis in Rats With Heart Failure After Myocardial Infarction Hypertension, February 1, 2004; 43(2): 229 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Berl Angiotensin-Converting Enzyme Inhibitors versus AT1 Receptor Antagonist in Cardiovascular and Renal Protection: The case for AT1 Receptor Antagonist J. Am. Soc. Nephrol., January 1, 2004; 15(90010): S71 - 76. [Abstract] [Full Text]
|
|
|
|
 |
|
 Z. Xie, M. Singh, D. A. Siwik, W. L. Joyner, and K. Singh Osteopontin Inhibits Interleukin-1{beta}-stimulated Increases in Matrix Metalloproteinase Activity in Adult Rat Cardiac Fibroblasts: ROLE OF PROTEIN KINASE C-{zeta} J. Biol. Chem., December 5, 2003; 278(49): 48546 - 48552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tiede, K. Stoter, C. Petrik, W.-B. Chen, H. Ungefroren, M.-L. Kruse, M. Stoll, T. Unger, and J. W Fischer Angiotensin II AT1-receptor induces biglycan in neonatal cardiac fibroblasts via autocrine release of TGF{beta} in vitro Cardiovasc Res, December 1, 2003; 60(3): 538 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsuda, E. Gao, L. Evangelisti, D. Markova, X. Ma, and M.-L. Chu Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes Cardiovasc Res, October 1, 2003; 59(4): 926 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. I. Jugdutt Ventricular Remodeling After Infarction and the Extracellular Collagen Matrix: When Is Enough Enough? Circulation, September 16, 2003; 108(11): 1395 - 1403. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Bittira, D. Shum-Tim, A. Al-Khaldi, and R. C-J. Chiu Mobilization and homing of bone marrow stromal cells in myocardial infarction Eur. J. Cardiothorac. Surg., September 1, 2003; 24(3): 393 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Yarbrough, R. Mukherjee, T. A. Brinsa, K. B. Dowdy, A. A. Scott, G. P. Escobar, C. Joffs, D. G. Lucas, F. A. Crawford Jr, and F. G. Spinale Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs J. Thorac. Cardiovasc. Surg., March 1, 2003; 125(3): 602 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mukherjee, T. A. Brinsa, K. B. Dowdy, A. A. Scott, J. M. Baskin, A. M. Deschamps, A. S. Lowry, G. P. Escobar, D. G. Lucas, W. M. Yarbrough, et al. Myocardial Infarct Expansion and Matrix Metalloproteinase Inhibition Circulation, February 4, 2003; 107(4): 618 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Manabe, T. Shindo, and R. Nagai Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy Circ. Res., December 13, 2002; 91(12): 1103 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M.C. Dixon A new altruist on the block: effects of adrenomedullin after myocardial infarction Cardiovasc Res, December 1, 2002; 56(3): 347 - 349. [Full Text] [PDF]
|
|
|
|
|
|
A. BEHFAR, L. V. ZINGMAN, D. M. HODGSON, J.-M. RAUZIER, G. C. KANE, A. TERZIC, and M. PUCEAT Stem cell differentiation requires a paracrine pathway in the heart FASEB J, October 1, 2002; 16(12): 1558 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gaertner, F. Prunier, M. Philippe, L. Louedec, J.-J. Mercadier, and J.-B. Michel Scar and pulmonary expression and shedding of ACE in rat myocardial infarction Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H156 - H164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Fraccarollo, P. Galuppo, J. Bauersachs, and G. Ertl Collagen accumulation after myocardial infarction: effects of ETA receptor blockade and implications for early remodeling: Presented in part at the 72nd Scientific Session of the American Heart Association, Atlanta, GA, USA, November 7-10, 1999, and published in abstract form (Circulation 1999;100(Suppl. 1):562) Cardiovasc Res, June 1, 2002; 54(3): 559 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Thibault, M.-J. Lacombe, L. M. Schnapp, A. Lacasse, F. Bouzeghrane, and G. Lapalme Upregulation of alpha 8beta 1-integrin in cardiac fibroblast by angiotensin II and transforming growth factor-beta 1 Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1457 - C1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J Bing Myocardial ischemia and infarction: growth of ideas Cardiovasc Res, July 1, 2001; 51(1): 13 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Ross and T. K. Borg Integrins and the Myocardium Circ. Res., June 8, 2001; 88(11): 1112 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Dostal Regulation of Cardiac Collagen : Angiotensin and Cross-Talk With Local Growth Factors Hypertension, March 1, 2001; 37(3): 841 - 844. [Full Text] [PDF]
|
|
|
|
 |
|
 K. T Weber and Yao Sun Recruitable ACE and tissue repair in the infarcted heart Journal of Renin-Angiotensin-Aldosterone System, December 1, 2000; 1(4): 295 - 303. [PDF]
|
|
|
|
|
|
N. A. Trueblood, Z. Xie, C. Communal, F. Sam, S. Ngoy, L. Liaw, A. W. Jenkins, J. Wang, D. B. Sawyer, O. H. L. Bing, et al. Exaggerated Left Ventricular Dilation and Reduced Collagen Deposition After Myocardial Infarction in Mice Lacking Osteopontin Circ. Res., May 25, 2001; 88(10): 1080 - 1087. [Abstract] [Full Text] [PDF]
|
|