Skip Navigation

Cardiovascular Research 2000 46(1):119-125; doi:10.1016/S0008-6363(00)00013-4
© 2000 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sugiyama, A.
Right arrow Articles by Hashimoto, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sugiyama, A.
Right arrow Articles by Hashimoto, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2000, European Society of Cardiology

Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart

Atsushi Sugiyamaa,*, Yutaka Yatomib, Yukio Ozakib and Keitaro Hashimotoa

aDepartment of Pharmacology, Yamanashi Medical University, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan
bDepartment of Laboratory Medicine, Yamanashi Medical University, Yamanashi, Japan

* Corresponding author. Tel.: +81-55-273-9504; fax: +81-55-273-6739 atsushis{at}res.yamanashi-med.ac.jp

Objective: Sphingosine 1-phosphate is a naturally occurring biologically active lysophospholipid. Recent studies suggested that sphingosine 1-phosphate is released into the blood flow from activated platelets upon stimulation to exert multiple biological phenomenon. The purpose of this study was to assess the effects of sphingosine 1-phosphate on sinus automaticity, ventricular contraction and coronary blood flow. Methods: The canine isolated, blood-perfused sinoatrial node and papillary muscle preparations were used. Results: Sphingosine 1-phosphate increased the sinoatrial rate, while it decreased the coronary blood flow, which was followed by a weak negative inotropic effect. These positive chronotropic and coronary vasoconstrictor effects were not attenuated by the β- and {alpha}-adrenoceptor antagonists atenolol and prazosin, respectively. Furthermore, sphingosine 1-phosphate did not affect the adenylate cyclase activity of the membrane preparations made from the canine right atrium and right ventricle, indicating the involvement of a novel signaling pathway in sphingosine 1-phosphate-induced cardiac effects. Conclusions: These results may provide a clue to better understanding the physiological as well as the pathophysiological regulation of sphingosine 1-phosphate in the heart.

KEYWORDS Lipid metabolism; Platelets; Second messengers; Sinus node; Vasoconstriction/dilation; Signal transduction


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
C. K. Means and J. H. Brown
Sphingosine-1-phosphate receptor signalling in the heart
Cardiovasc Res, May 1, 2009; 82(2): 193 - 200.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
K. Takabe, S. W. Paugh, S. Milstien, and S. Spiegel
"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets
Pharmacol. Rev., June 1, 2008; 60(2): 181 - 195.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.