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Cardiovascular Research 2000 45(4):860-865; doi:10.1016/S0008-6363(99)00388-0
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy

Diana Jarretaa, Josefina Orúsb, Antoni Barrientosc, Oscar Miróa, Eulàlia Roigb, Magdalena Herasb, Carlos T Moraesc, Francesc Cardellacha and Jordi Casademonta,*

aGrup d’Investigació Muscular, Departament de Medicina, Hospital Clinic i Provincial, IDIBAPS, Facultat de Medicina, UB, Villarroel 170, 08036 Barcelona, Spain
bServei de Cardiologia, Institut de Malalties Cardiovasculars, Hospital Clinic i Provincial, Barcelona, Spain
cDepartment of Neurology and Cell Biology and Anatomy, University of Miami, School of Medicine, Miami, FL, USA

* Corresponding author. Tel.: +34-93-227-5539; fax: +34-93-227-5539 jordi{at}medicina.ub.es

Objective: To study the mitochondrial respiratory chain enzyme activities in patients with idiopathic dilated cardiomyopathy (IDC). Methods: Mitochondrial respiratory chain enzyme activities were assessed spectrophotometrically in left ventricular tissue of 17 patients with IDC undergoing cardiac transplantation, as well as in two groups of controls: a group of six patients suffering from ischemic dilated cardiomyopathy (IC) also undergoing cardiac transplantation, and a group of 17 organ donors considered normal from a cardiac point of view. Cytochrome b gene from three IDC patients whose complex III activity was particularly low and from three controls was also sequenced. Results: We found that complex III enzymatic activity was lower not only in IDC but also in IC patients when compared with normal controls. When analysing cytochrome b gene we only found neutral polymorphisms previously described. Conclusions: In view of such results, we believe that the decrease of respiratory chain complex III activity found in some cases of IDC is a secondary phenomenon, and not due to a primary mitochondrial disease.

KEYWORDS Cardiomyopathy; Energy metabolism; Gene therapy; Mitochondria; Oxidative phosphorylation


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