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Cardiovascular Research 2000 45(3):795-801; doi:10.1016/S0008-6363(99)00264-3
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Future perspectives and potential implications of cardiac myocyte apoptosis

Armin Haunstettera and Seigo Izumob,*

aDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany
bCardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

* Corresponding author. Tel.: +1-617-667-4858; fax: +1-617-975-5268

Recent advances in the understanding of the molecular mechanisms of apoptosis has gained increasing interest in the cardiovascular research community. Apoptotic myocyte loss has been detected in different cardiac disease states such as ischemic heart disease and congestive heart failure. In addition, some evidence for the molecular mechanisms in cardiac myocyte apoptosis has been evolving, although at present the implications thereof for clinical cardiac disease are not known in most of the cases. Based on these new insights, it is the intention of this article to highlight some topics in apoptosis research that might be of particular interest to define the future role and potentials of new therapeutic approaches aimed at preventing myocyte apoptosis.

KEYWORDS Apoptosis; Myocytes; Growth factors; Mitochondria


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