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Cardiovascular Research 2000 45(3):756-765; doi:10.1016/S0008-6363(99)00270-9
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Apoptosis in inflammatory–fibroproliferative disorders of the vessel wall

Kenneth Walsha,b,* and Jeffrey M. Isnera

aDivisions of Cardiovascular Research and Vascular Medicine, St. Elizabeth's Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
bProgram in Cell, Molecular and Developmental Biology, Sackler School of Biomedical Studies, Tufts University School of Medicine, Boston, MA 02135, USA

* Corresponding author. Tel.: +1-617-562-7501; fax: +1-617-562-7506 kwalsh{at}opal.tufts.edu

Apoptotic cell death is a hallmark of inflammatory–fibroproliferative disorders of the vessel wall. Here, we review what is currently known about cell death within atherosclerotic and restenotic lesions. We also examine evidence suggesting that inflammatory cells contribute to the regulation of cell turnover within these lesions, and discuss the molecules expressed by vascular cells that modulate these processes. In toto, these studies suggest that apoptosis is prevalent in vascular lesions, controlling the viability of both inflammatory and vascular cells, and thus determining the cellular composition of the vessel wall.

KEYWORDS Apoptosis; Arteries; Atherosclerosis; Infection/inflammation; Smooth muscle


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