© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
Reduction in the response to coronary and iliac artery injury with photodynamic therapy using 5-aminolaevulinic acid
aNational Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, London, UK
bHatter Institute, Division of Cardiology, Department of Medicine, Royal Free and University College Medical School, London, UK
cVascular Unit, Department of Surgery, Royal Free and University College Medical School, London, UK
* Corresponding author. Cardiothoracic Directorate, 4th Floor, Jules Thorn Institute, The Middlesex Hospital, Mortimer Street, London W1N 8AA, UK. Tel.: +44-171-380-9656; fax: +44-171-380-9415 j.mcewan{at}ucl.ac.uk
Objective: Photodynamic therapy (PDT) uses red light (non-thermal, non-ionising) to activate a previously administered photosensitising drug. This inhibits neointimal hyperplasia in injured arteries in small animals where it appears safe and well tolerated. Our aim was to develop a method for percutaneous application of PDT to iliac and coronary arteries in a large animal model and investigate its influence on the remodeling and intimal hyperplastic response to balloon injury. Methods: Studies were undertaken on 13 juvenile Large White–Landrace crossbred pigs (15–20 kg). After intravenous administration of the photosensitising agent 5-amino laevulinic acid (ALA), the arterial tree was accessed via the left common carotid artery and balloon injuries made by overdistension in both common iliacs (thirteen animals) and one or two main coronary arteries (eight animals). Half the injured sites were then illuminated with red laser light transmitted via the catheter. Animals were culled 28 days later and tissue harvested for histomorphometry. Results: Compared with control injured vessels, PDT treated, balloon injured coronary arteries had a larger lumen (1.4 vs. 0.8 mm2, P=0.002), larger area within the external elastic lamina (2.8 vs. 2.2 mm2, P=0.006) and smaller area of neointimal hyperplasia (0.4 vs. 0.7 mm2, P=0.06), 28 days after intervention. Less neointimal hyperplasia and the absence of negative remodeling resulted in the lumen of PDT-treated, injured segments being the same as that of adjacent reference segments (1.5 vs. 1.6 mm2). Similar trends, but with smaller differences, were seen in the iliac vessels. Conclusions: Intra-arterial, trans-catheter PDT favourably influences the arterial response to balloon injury in both the coronary and peripheral circulations. This technique offers a promising new approach to restenosis after endovascular procedures.
KEYWORDS Arteries; Angioplasty; Remodeling; Restenosis
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